immunosuppression
PD-L1 in Extracellular Vesicles May Help Glioblastoma Evade Immunotherapies
PD-L1 in Extracellular Vesicles May Help Glioblastoma Evade Immunotherapies
Jim Daley | Mar 8, 2018
The discovery suggests that the immune checkpoint can operate at a further distance from tumor cells than previously believed.
Immune Checkpoint Found Lacking in Type 1 Diabetes
Immune Checkpoint Found Lacking in Type 1 Diabetes
Ruth Williams | Nov 15, 2017
Boosting levels of a the immunosuppressive protein PD-L1 in blood stem cells halts diabetes in a mouse model of the disease.
An Immunological Timeline for Pregnancy
An Immunological Timeline for Pregnancy
Catherine Offord | Sep 1, 2017
A new study uses blood samples from pregnant women to track changes in the immune system leading up to birth, and predicts gestational age from the mothers’ immune signatures.
Inhibiting Sperm Protein Causes Infertility
Inhibiting Sperm Protein Causes Infertility
Karen Zusi | Oct 5, 2015
Two drugs targeting a protein in sperm cause reversible infertility in male mice, providing new hope for a male contraceptive.
Done with Immunosuppressants
Done with Immunosuppressants
Jef Akst | Jul 3, 2014
Adult sickle-cell patients have safely stopped taking their immunosuppressant medication thanks to a new type of blood stem-cell transplant.
T cells and Transplantation
T cells and Transplantation
Ruth Williams | Nov 13, 2013
Drug-resistant immune cells protect patients from graft-versus-host disease after bone marrow transplant.
Transplant Without Drugs?
Edyta Zielinska | Mar 8, 2012
A new method for transplanting immunologically mismatched organs may remove the need for life-long immunosuppressive drugs to prevent rejection.