Despite a solid understanding of the biological basis of fragile X syndrome, researchers have struggled to develop effective treatments.

A case study of a family demonstrates that different genetic mutations from the two parents cause severe heart disease symptoms in the children.

Variation in the number of CGG repeats in the FMR1 gene at the bottom of the X chromosome can lead to increased levels of mRNA or decreased levels of protein—both conditions that cause disease.

Two research groups demonstrate that in Caenorhabditis elegans, behavioral traits can be passed down through the germline to future generations, even though they aren’t hard-wired.

A study suggests that the direct transfer of DNA methylation marks from one generation to the next is much less common than scientists previously thought.

The recent discovery of 17 people who have inherited maternal and paternal lines of mitochondrial DNA has major ramifications for medical and ancestry research.

Researchers identify unique cases in which people inherited mitochondrial DNA not just from their mother but also from their father.

Learning about your own genetic idiosyncrasies comes with complex emotions.

An analysis of 14,000 genomes reveals regions where new mutations are more likely to develop.

Mitochondrial DNA polymerase is necessary for the destruction of paternal mtDNA in fruit fly sperm, scientists show.

This year marks the centennial of Calvin Bridges’s description of nondisjunction as proof that chromosomes are vehicles for inheritance.

Raphael Weldon’s critiques of Mendelian principles were 100 years ahead of his time.

Without a vacuole, cell-cycle progression stalls out in yeast cells.

How one generation’s experience can affect the next

The stressors a female rat experiences during pregnancy can have repercussions for her granddaughters, a study shows. 

Examining more than 20 years of Swedish birth records, researchers determine that autism risk is influenced equally by genetic and environmental factors.

More than school or family environment, a child’s genetics influences high school exam results.

Mice appear to pass certain fears onto their offspring, according to a new study.

Infested plants pass on a defense memory of pests and pathogens to help the next generation withstand invasions.