blue-gloved hands injecting mouse with syringe
Sex of Researcher Influences Ketamine’s Effects in Mice: Study
The findings likely have implications for animal research far beyond the study of antidepressants.
Sex of Researcher Influences Ketamine’s Effects in Mice: Study
Sex of Researcher Influences Ketamine’s Effects in Mice: Study

The findings likely have implications for animal research far beyond the study of antidepressants.

The findings likely have implications for animal research far beyond the study of antidepressants.

lab mice
Bright purple and orange lactobacillus bacteria.
How a Specific Gut Bacterium May Cause Type 1 Diabetes
Dan Robitzski | Aug 25, 2022
A bacterium that produces an insulin-like peptide can give mice type 1 diabetes, and infection with the microbe seems to predict the onset of the disease in humans, a study finds.
mouse nose peeking out from between two yellow objects
Not-so-Mellow Yellow: Pregnant Mice’s Urine Stresses Out Males
Sophie Fessl | Jun 20, 2022
An odorant found in the pee of pregnant mice—and in bananas—induces stress but also relieves pain in male mice, a study shows.
A small, brown mouse runs on a narrow, miniature treadmill
How Exercise Helps Mice Fight Pancreatic Cancer
Dan Robitzski | Jun 15, 2022
A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.
Artist’s rendition of bright blue microbes among intestinal lining
Study Links Depression with High Levels of an Amino Acid
Dan Robitzski | Jun 14, 2022
Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.
A white lab mouse peers over the wall of a sprawling maze
Bacterial Metabolite May Regulate Cognition in Mice
Sophie Fessl | Jun 3, 2022
Microbes in the gut influence the death of support cells in the brain by producing isoamylamine, a study suggests.
A colorized transmission electron microscope image of an oligodendrocyte (blue) surrounded by cells that it coated in myelin (red outlines).
Brain Fluid from Youngsters Gives Old Mice a Memory Boost
Dan Robitzski | May 11, 2022
A growth factor found in the cerebrospinal fluid of young mice triggered the proliferation of myelin-making cells when injected into the brains of older mice.
A white mouse huddles with some of her nine-day-old pups.
In Vivo Gene Therapy Cures Infertility in Mice
Dan Robitzski | May 2, 2022
Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.
A two-pronged needle, a glass vial of smallpox vaccine, and a syringe sit on a blue surface.
Smallpox Vaccine Recruits Skin Bacteria to Fight Disease
Patience Asanga | Apr 26, 2022
A mouse study points to a possible mechanism by which the smallpox vaccine helped eradicate the disease in the 1980s.
Ken Paigen
Former Jackson Lab Director Ken Paigen Dies
Shawna Williams | Feb 20, 2020
The geneticist’s long career included leading the laboratory’s recovery from a devastating 1989 fire.
Johannes Kohl Untangles the Neural Circuitry Behind Instinct
Nicoletta Lanese | Oct 1, 2019
The Francis Crick Institute neurobiologist aims to learn how physiological states, such as hunger, alter information processing in the brain.
EPA Aims to Drastically Reduce Animal Testing
Emily Makowski | Sep 11, 2019
The agency plans to stop funding virtually all toxicology studies in mammals by 2035.
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
When Should Service Dogs Be Admitted into the Lab?
Jef Akst | Nov 1, 2018
Becoming a neuroscientist with a service dog by your side presents numerous challenges. Joey Ramp, who went back to college to study her own post-traumatic stress disorder, is learning this the hard way.
CRISPR Gene Drive Used to Alter Mouse Coat Color
Shawna Williams | Jul 9, 2018
It’s the first demonstration of the technology in mammals.
Mouse Pups Infected With Zika Show Symptoms Into Adulthood
Ashley Yeager | Jun 6, 2018
The results suggest the virus could severely alter brain development in infants infected after birth, but blocking a signaling protein early on might ease certain symptoms.
What Scientists Can Learn From South African Labs About Water Conservation
Linda Nordling | Feb 27, 2018
As Cape Town nears drying up, researchers there have come up with simple ways to dramatically cut back on water use.  
Image of the Day: Mouse Pupil
The Scientist Staff and The Scientist Staff | Jan 19, 2018
Pupil constriction during sleep may protect the murine brain from being awakened by sudden flashes of light.
Image of the Day: Muscle Bouquet 
The Scientist Staff and The Scientist Staff | Jan 16, 2018
Lab-grown muscle stem cells from mice mimic the formation of muscle fibers in vivo. 
A Database of Genetic Differences Among Lab Mice
Ashley P. Taylor | Aug 7, 2017
Researchers have catalogued mutations in the coding regions of 36 of the most important mouse strains.