A colorized transmission electron microscope image of an oligodendrocyte (blue) surrounded by cells that it coated in myelin (red outlines).
Brain Fluid from Youngsters Gives Old Mice a Memory Boost
A growth factor found in the cerebrospinal fluid of young mice triggered the proliferation of myelin-making cells when injected into the brains of older mice.
Brain Fluid from Youngsters Gives Old Mice a Memory Boost
Brain Fluid from Youngsters Gives Old Mice a Memory Boost

A growth factor found in the cerebrospinal fluid of young mice triggered the proliferation of myelin-making cells when injected into the brains of older mice.

A growth factor found in the cerebrospinal fluid of young mice triggered the proliferation of myelin-making cells when injected into the brains of older mice.

lab mice

A white mouse huddles with some of her nine-day-old pups.
In Vivo Gene Therapy Cures Infertility in Mice
Dan Robitzski | May 2, 2022
Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.
A two-pronged needle, a glass vial of smallpox vaccine, and a syringe sit on a blue surface.
Smallpox Vaccine Recruits Skin Bacteria to Fight Disease
Patience Asanga | Apr 26, 2022
A mouse study points to a possible mechanism by which the smallpox vaccine helped eradicate the disease in the 1980s.
Ken Paigen
Former Jackson Lab Director Ken Paigen Dies
Shawna Williams | Feb 20, 2020
The geneticist’s long career included leading the laboratory’s recovery from a devastating 1989 fire.
Johannes Kohl Untangles the Neural Circuitry Behind Instinct
Nicoletta Lanese | Oct 1, 2019
The Francis Crick Institute neurobiologist aims to learn how physiological states, such as hunger, alter information processing in the brain.
EPA Aims to Drastically Reduce Animal Testing
Emily Makowski | Sep 11, 2019
The agency plans to stop funding virtually all toxicology studies in mammals by 2035.
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
When Should Service Dogs Be Admitted into the Lab?
Jef Akst | Nov 1, 2018
Becoming a neuroscientist with a service dog by your side presents numerous challenges. Joey Ramp, who went back to college to study her own post-traumatic stress disorder, is learning this the hard way.
CRISPR Gene Drive Used to Alter Mouse Coat Color
Shawna Williams | Jul 9, 2018
It’s the first demonstration of the technology in mammals.
Mouse Pups Infected With Zika Show Symptoms Into Adulthood
Ashley Yeager | Jun 6, 2018
The results suggest the virus could severely alter brain development in infants infected after birth, but blocking a signaling protein early on might ease certain symptoms.
What Scientists Can Learn From South African Labs About Water Conservation
Linda Nordling | Feb 27, 2018
As Cape Town nears drying up, researchers there have come up with simple ways to dramatically cut back on water use.  
Image of the Day: Mouse Pupil
The Scientist Staff, The Scientist Staff | Jan 19, 2018
Pupil constriction during sleep may protect the murine brain from being awakened by sudden flashes of light.
Image of the Day: Muscle Bouquet 
The Scientist Staff, The Scientist Staff | Jan 16, 2018
Lab-grown muscle stem cells from mice mimic the formation of muscle fibers in vivo. 
A Database of Genetic Differences Among Lab Mice
Ashley P. Taylor | Aug 7, 2017
Researchers have catalogued mutations in the coding regions of 36 of the most important mouse strains.
Molecular Trigger for Organ Rejection in Mice Identified
Diana Kwon | Jun 27, 2017
The cell-surface receptor, SIRP-alpha, initiates the innate immune response in hosts.  
Immunological Differences Between Lab Mice and Wild Mice
Diana Kwon | May 5, 2017
Discrepancies in the populations’ immune systems suggest murine models of immunological disorders possess more limitations than scientists had appreciated.
Why Obese Mice Prefer To Sit Around All Day
Joshua A. Krisch | Jan 2, 2017
A study links excess body weight in the rodents with dopamine receptor inactivity and reduced movement.
Study: Enriched Housing Changes Murine T Cells
Jef Akst | Oct 3, 2016
Mice that live in a more-stimulating environment for two weeks appear to develop a more-inflammatory immune state that might help protect the animals against infection. 
Immune Defect Detected in Knockout Mice
Tanya Lewis | May 20, 2016
Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.
Drug Spurs Digestion
Jef Akst | Jan 6, 2015
A new drug shows promise as a weight-loss solution in mice, prompting the animals to burn calories in the absence of a meal.