Former Jackson Lab Director Ken Paigen Dies
Former Jackson Lab Director Ken Paigen Dies
The geneticist’s long career included leading the laboratory’s recovery from a devastating 1989 fire.
Former Jackson Lab Director Ken Paigen Dies
Former Jackson Lab Director Ken Paigen Dies

The geneticist’s long career included leading the laboratory’s recovery from a devastating 1989 fire.

The geneticist’s long career included leading the laboratory’s recovery from a devastating 1989 fire.

lab mice
Johannes Kohl Untangles the Neural Circuitry Behind Instinct
Johannes Kohl Untangles the Neural Circuitry Behind Instinct
Nicoletta Lanese | Oct 1, 2019
The Francis Crick Institute neurobiologist aims to learn how physiological states, such as hunger, alter information processing in the brain.
EPA Aims to Drastically Reduce Animal Testing
EPA Aims to Drastically Reduce Animal Testing
Emily Makowski | Sep 11, 2019
The agency plans to stop funding virtually all toxicology studies in mammals by 2035.
First Successful Gene Drive in Mammals
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
When Should Service Dogs Be Admitted into the Lab?
When Should Service Dogs Be Admitted into the Lab?
Jef Akst | Nov 1, 2018
Becoming a neuroscientist with a service dog by your side presents numerous challenges. Joey Ramp, who went back to college to study her own post-traumatic stress disorder, is learning this the hard way.
CRISPR Gene Drive Used to Alter Mouse Coat Color
CRISPR Gene Drive Used to Alter Mouse Coat Color
Shawna Williams | Jul 9, 2018
It’s the first demonstration of the technology in mammals.
Mouse Pups Infected With Zika Show Symptoms Into Adulthood
Mouse Pups Infected With Zika Show Symptoms Into Adulthood
Ashley Yeager | Jun 6, 2018
The results suggest the virus could severely alter brain development in infants infected after birth, but blocking a signaling protein early on might ease certain symptoms.
What Scientists Can Learn From South African Labs About Water Conservation
What Scientists Can Learn From South African Labs About Water Conservation
Linda Nordling | Feb 27, 2018
As Cape Town nears drying up, researchers there have come up with simple ways to dramatically cut back on water use.  
Image of the Day: Mouse Pupil
Image of the Day: Mouse Pupil
The Scientist Staff, The Scientist Staff | Jan 19, 2018
Pupil constriction during sleep may protect the murine brain from being awakened by sudden flashes of light.
Image of the Day: Muscle Bouquet 
Image of the Day: Muscle Bouquet 
The Scientist Staff, The Scientist Staff | Jan 16, 2018
Lab-grown muscle stem cells from mice mimic the formation of muscle fibers in vivo. 
A Database of Genetic Differences Among Lab Mice
A Database of Genetic Differences Among Lab Mice
Ashley P. Taylor | Aug 7, 2017
Researchers have catalogued mutations in the coding regions of 36 of the most important mouse strains.
Molecular Trigger for Organ Rejection in Mice Identified
Molecular Trigger for Organ Rejection in Mice Identified
Diana Kwon | Jun 27, 2017
The cell-surface receptor, SIRP-alpha, initiates the innate immune response in hosts.  
Immunological Differences Between Lab Mice and Wild Mice
Immunological Differences Between Lab Mice and Wild Mice
Diana Kwon | May 5, 2017
Discrepancies in the populations’ immune systems suggest murine models of immunological disorders possess more limitations than scientists had appreciated.
Why Obese Mice Prefer To Sit Around All Day
Why Obese Mice Prefer To Sit Around All Day
Joshua A. Krisch | Jan 2, 2017
A study links excess body weight in the rodents with dopamine receptor inactivity and reduced movement.
Study: Enriched Housing Changes Murine T Cells
Study: Enriched Housing Changes Murine T Cells
Jef Akst | Oct 3, 2016
Mice that live in a more-stimulating environment for two weeks appear to develop a more-inflammatory immune state that might help protect the animals against infection. 
Immune Defect Detected in Knockout Mice
Immune Defect Detected in Knockout Mice
Tanya Lewis | May 20, 2016
Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.
Drug Spurs Digestion
Drug Spurs Digestion
Jef Akst | Jan 6, 2015
A new drug shows promise as a weight-loss solution in mice, prompting the animals to burn calories in the absence of a meal.
May the Best Rodent Win
May the Best Rodent Win
Molly Sharlach | Jan 1, 2015
Are mice, considered by some to be the less intelligent rodent, edging out rats as laboratory models of decision making?
Upside of Early-Life Stress?
Upside of Early-Life Stress?
Kate Yandell | Nov 18, 2014
Mice raised under stressful conditions are more adaptable as adults—and may pass this trait on to their pups.
To Kill a Lab Rat
To Kill a Lab Rat
Kerry Grens | Nov 4, 2014
Some institutions are changing their protocols for rodent euthanasia, as research finds there may be more humane methods.