Skip to main content

Sex of Researcher Influences Ketamine’s Effects in Mice: Study

The findings likely have implications for animal research far beyond the study of antidepressants.

Written byShawna Williams
| 3 min read
blue-gloved hands injecting mouse with syringe
Register for free to listen to this article
Listen with Speechify
0:00
3:00

Todd Gould’s lab members couldn’t replicate their experiments. As New Scientist reports, they got different results when testing the antidepressant effects of ketamine in mice depending on which members of the lab conducted the experiment, which involved measuring how long the mice would swim when placed in a tank. Gould, a psychiatry researcher at the University of Maryland School of Medicine, had read a 2014 study that found the presence of men, but not women, dulls mice’s pain, and according to a university news release, his team also heard anecdotes from other labs about experimental results that seemed to be influenced by researcher sex. So they decided to test whether this could explain the inconsistencies they saw.

The team reported in an August 30 Nature Neuroscience paper that the sex of researchers working with mice did indeed influence outcomes involving ketamine treatment, with the scent of human males triggering the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

  • Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor’s degree in biochemistry from Colorado College and a graduate certificate in science communication from the University of California, Santa Cruz. Previously, she worked as a freelance editor and writer, and in the communications offices of several academic research institutions. As news director, Shawna assigned and edited news, opinion, and in-depth feature articles for the website on all aspects of the life sciences. She is based in central Washington State, and is a member of the Northwest Science Writers Association and the National Association of Science Writers.

    View Full Profile

Related Topics

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi
Mapping Clonal Mosaicism in Aging Tissues

Mapping Clonal Mosaicism in Aging Tissues

Mission bio

Products

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo
Conceptual image of ice and frost.

The VAULT100 PRO: Inside the most advanced Stirling Ultracold ULT freezer ever built.

Stirling Ultracold logo