What’s the Deal with Bacterial Nanotubes?
What’s the Deal with Bacterial Nanotubes?
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
What’s the Deal with Bacterial Nanotubes?
What’s the Deal with Bacterial Nanotubes?

Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?

Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?

replication
Infographic: Sources of Variation in Bacterial Nanotube Studies
Infographic: Sources of Variation in Bacterial Nanotube Studies
Sruthi S. Balakrishnan | Jun 1, 2021
Differences in how researchers prepare and image samples can lead to discrepancies in their results.
Human Cells Can Synthesize DNA in Their Cytoplasm
Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez | Feb 8, 2021
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
Gene Splicing Pioneer Dale Kaiser Dies
Gene Splicing Pioneer Dale Kaiser Dies
Ashley Yeager | Jun 29, 2020
Working with a virus that infects bacteria, the Stanford University biochemist and developmental biologist helped to develop a way to stitch DNA together, a discovery that gave rise to genetic engineering.
Image of the Day: Coronavirus in 3D
Image of the Day: Coronavirus in 3D
Amy Schleunes | Mar 25, 2020
At Bessy II, a synchrotron radiation facility in Berlin, scientists use X-rays to study the structure of SARS-CoV-2.
DNA Damage Linked to Brain Overgrowth in Autism
DNA Damage Linked to Brain Overgrowth in Autism
Abby Olena | Feb 5, 2020
Cell lines from individuals with macrocephalic autism spectrum disorder have an increased number of double-strand breaks in the DNA of long neural genes.
Study Refutes Findings that Acidification Affects Fish Behavior
Study Refutes Findings that Acidification Affects Fish Behavior
Emma Yasinski | Jan 8, 2020
The new experiments use standardized methods and video recordings, but some researchers stand by earlier evidence that ocean pH influences coral reef fish’s response to predator cues.
Image of the Day: Fractal Formation
Image of the Day: Fractal Formation
Emily Makowski | Nov 4, 2019
A mixture of chemicals induces reactions reminiscent of life on pyrite.
Replication Refutes Study Linking Neuroimaging to Genetics
Replication Refutes Study Linking Neuroimaging to Genetics
Emma Yasinski | Sep 30, 2019
The original experiment found brain activity as measured by fMRI was tied to particular genetic variants.
Two Studies Fail to Replicate Magnetogenetics Research
Two Studies Fail to Replicate Magnetogenetics Research
Katarina Zimmer | Sep 20, 2019
The new work calls into question the idea that neurons can be genetically engineered to fire in response to magnetic fields, a setback for the budding technique.
Half the Time, Psychology Results Not Reproducible: Study
Half the Time, Psychology Results Not Reproducible: Study
Ashley P. Taylor | Nov 20, 2018
These failures were not due to differences among sample populations.
Study Challenges CRISPR Method for Making Conditional Knockout Mice
Study Challenges CRISPR Method for Making Conditional Knockout Mice
Sukanya Charuchandra | Sep 28, 2018
Researchers from 17 labs report low efficacy rates for the popular technique.
Latest Effort to Replicate Psych Studies Yields 62 Percent Success
Latest Effort to Replicate Psych Studies Yields 62 Percent Success
Kerry Grens | Aug 27, 2018
Among the experiments that came to the same result as the original, the effect size was smaller on average.
Replication Failures Highlight Biases in Ecology and Evolution Science
Replication Failures Highlight Biases in Ecology and Evolution Science
Yao-Hua Law | Aug 1, 2018
As robust efforts fail to reproduce findings of influential zebra finch studies from the 1980s, scientists discuss ways to reduce bias in such research.
Horizontal Gene Transfer in Bdelloid Rotifers Questioned
Horizontal Gene Transfer in Bdelloid Rotifers Questioned
Abby Olena | Jul 12, 2018
A re-analysis of sequencing data from a 2016 study of these tiny metazoans reveals possible contamination, rather than an exchange of DNA among species.
Latest Reproducibility Project Study Fails to Replicate
Latest Reproducibility Project Study Fails to Replicate
Kerry Grens | Mar 13, 2018
Researchers did not observe the same link between a bacterium and human colon cancer that prior investigators had reported.
Pestilent Spread
Pestilent Spread
The Scientist Staff | Feb 28, 2018
See the University of Pennsylvania's David Roos explain the process of parasite replication.
One Way to Fix Reproducibility Problems: Train Scientists Better
One Way to Fix Reproducibility Problems: Train Scientists Better
Katarina Zimmer | Nov 28, 2017
Leonard Freedman, president of the Global Biological Standards Institute, discusses the causes of irreproducible science and his latest effort to spread best practices.
Final Nail Hammered into NgAgo Coffin
Final Nail Hammered into NgAgo Coffin
Kerry Grens | Aug 3, 2017
The paper describing the gene-editing method is retracted.
Preclinical Cancer Studies Not as Reproducible as Thought
Preclinical Cancer Studies Not as Reproducible as Thought
Jef Akst | Jun 30, 2017
Researchers overestimate the reliability of findings from animal studies that are part of the Reproducibility Project: Cancer Biology.