irreplicability

Low participant numbers render the results of many studies based on brain scans unreliable, an analysis finds.

When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.

Five independent groups got different results in a drug-response experiment, despite sharing protocols, reagents, and cell lines. The researchers identify technical variables that could be to blame.

In the 1930s, parapsychologist Joseph Banks Rhine aimed to use scientific methods to confirm the existence of extrasensory perception, but faced criticisms of dubious analyses and irreproducible results.

Budget issues are limiting the number of studies the Reproducibility Project: Cancer Biology will try to re-do.

From tossing out cross-contaminated cell lines to flagging genomic misnomers, a push is on to tidy up biomedical research.

Despite dramatic increases in publications, the last 50 years have seen relatively little return on investment for US public health, a study suggests.

Half of basic science studies cannot be replicated, according to a new analysis—to the tune of $28 billion a year in the U.S.

Should there be standard protocols for how researchers attempt to reproduce the work of others?

A hormone thought to make murine insulin-secreting cells proliferate in mice did not perform in replication studies.

Scientists are taking to social media to challenge weak research, share replication attempts in real time, and counteract hype. Will this online discourse enrich the scientific process?

Stanford University starts new center to study how scientific research can be improved.

Mice become stressed in the presence of male, but not female, experimenters, triggering a physiological response that dampens pain.

Nearly two months after researchers published papers showing that they could induce pluripotency with an external stressor, the work’s validity is still being challenged.

Human vs. dog brains; widespread neuronal regeneration in human adult brain; honeybee disease strikes wild insects; trouble replicating stress-induced stem cells

Researchers report difficulty replicating the results of studies touting a new method to reprogram stem cells.

The federal agency speaks out about how to improve the quality of scientific research.

The journal is sharpening its review of life science papers and giving authors additional space to document more detailed methods.