Research Teams Reach Different Results From Same Brain-Scan Data
Research Teams Reach Different Results From Same Brain-Scan Data
When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.
Research Teams Reach Different Results From Same Brain-Scan Data
Research Teams Reach Different Results From Same Brain-Scan Data

When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.

When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.

irreplicability
Potential Causes of Irreproducibility Revealed
Potential Causes of Irreproducibility Revealed
Abby Olena | Jul 11, 2019
Five independent groups got different results in a drug-response experiment, despite sharing protocols, reagents, and cell lines. The researchers identify technical variables that could be to blame.
ESP on Trial
ESP on Trial
Catherine Offord | Sep 1, 2016
In the 1930s, parapsychologist Joseph Banks Rhine aimed to use scientific methods to confirm the existence of extrasensory perception, but faced criticisms of dubious analyses and irreproducible results.
Reproducibility Initiative Shrinks
Reproducibility Initiative Shrinks
Kerry Grens | Dec 3, 2015
Budget issues are limiting the number of studies the Reproducibility Project: Cancer Biology will try to re-do.
The Great Big Clean-Up
The Great Big Clean-Up
Kerry Grens | Sep 1, 2015
From tossing out cross-contaminated cell lines to flagging genomic misnomers, a push is on to tidy up biomedical research.
Report: Impact of Biomedical Research Slipping
Report: Impact of Biomedical Research Slipping
Jef Akst | Aug 18, 2015
Despite dramatic increases in publications, the last 50 years have seen relatively little return on investment for US public health, a study suggests.
The Cost of Irreproducible Research
The Cost of Irreproducible Research
Kerry Grens | Jun 10, 2015
Half of basic science studies cannot be replicated, according to a new analysis—to the tune of $28 billion a year in the U.S.
The Rules of Replication
The Rules of Replication
Kerry Grens | Nov 1, 2014
Should there be standard protocols for how researchers attempt to reproduce the work of others?
Diabetes “Breakthrough” Breaks Up
Diabetes “Breakthrough” Breaks Up
Kerry Grens | Oct 27, 2014
A hormone thought to make murine insulin-secreting cells proliferate in mice did not perform in replication studies.
Setting the Record Straight
Setting the Record Straight
Daniel Cossins | Oct 1, 2014
Scientists are taking to social media to challenge weak research, share replication attempts in real time, and counteract hype. Will this online discourse enrich the scientific process?
Researching Research
Researching Research
Jef Akst | Apr 28, 2014
Stanford University starts new center to study how scientific research can be improved.
Men Trigger Mouse Stress
Men Trigger Mouse Stress
Jef Akst | Apr 28, 2014
Mice become stressed in the presence of male, but not female, experimenters, triggering a physiological response that dampens pain.
STAP Drama Continues
STAP Drama Continues
Jef Akst | Mar 24, 2014
Nearly two months after researchers published papers showing that they could induce pluripotency with an external stressor, the work’s validity is still being challenged.
Week in Review: February 17–21
Week in Review: February 17–21
Tracy Vence | Feb 21, 2014
Human vs. dog brains; widespread neuronal regeneration in human adult brain; honeybee disease strikes wild insects; trouble replicating stress-induced stem cells
Stress-Induced Stem Cell Method Questioned
Stress-Induced Stem Cell Method Questioned
Tracy Vence | Feb 19, 2014
Researchers report difficulty replicating the results of studies touting a new method to reprogram stem cells.
NIH Tackles Irreproducibility
NIH Tackles Irreproducibility
Jef Akst | Jan 28, 2014
The federal agency speaks out about how to improve the quality of scientific research.
Nature Announces Reproducibility Initiative
Nature Announces Reproducibility Initiative
Kate Yandell | Apr 25, 2013
The journal is sharpening its review of life science papers and giving authors additional space to document more detailed methods.