Years of Prozac Alter Lipids in Young Monkeys’ Brains: Study
Years of Prozac Alter Lipids in Young Monkeys’ Brains: Study
Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.
Years of Prozac Alter Lipids in Young Monkeys’ Brains: Study
Years of Prozac Alter Lipids in Young Monkeys’ Brains: Study

Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.

Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.

antidepressants
Deep Brain Stimulation Improves Depression Symptoms: Study
Deep Brain Stimulation Improves Depression Symptoms: Study
Catherine Offord | Oct 7, 2019
The effects of the therapy in a small group of  patients were long-lasting, researchers say, adding to evidence that the approach works for treatment-resistant depression.
Rabbit Study May Hint at Origin of Female Orgasm in Humans
Rabbit Study May Hint at Origin of Female Orgasm in Humans
Catherine Offord | Oct 1, 2019
It could be a throwback to a mechanism that induces ovulation during sex, researchers propose, but not everyone thinks the results can be extrapolated to people.
Antidepressant Approvals Could Herald New Era in Psychiatric Drugs
Antidepressant Approvals Could Herald New Era in Psychiatric Drugs
Bianca Nogrady | Oct 1, 2019
The FDA has given the green light to the first major new classes of antidepressant therapies in decades, opening up new avenues for therapeutic development.
Forced-Swim Test Criticized as Uninformative, Cruel
Forced-Swim Test Criticized as Uninformative, Cruel
Catherine Offord | Jul 22, 2019
Some researchers and animal rights groups are amplifying their opposition to an assay that measures how long a rodent tries to stay afloat.
How the Brain Changes on Ketamine: A Live Animal Study
How the Brain Changes on Ketamine: A Live Animal Study
Ruth Williams | Apr 11, 2019
The drug promotes and sustains brain cell connectivity in mice, reversing the effects of chronic stress.
Esketamine, a Treatment for Depression, Receives FDA Approval
Esketamine, a Treatment for Depression, Receives FDA Approval
Carolyn Wilke | Mar 6, 2019
The nasal spray to ease intractable depression appears on the US market after decades without novel antidepressant treatments.
Effects of Antidepressants Span Three Generations in Fish
Effects of Antidepressants Span Three Generations in Fish
Diana Kwon | Dec 10, 2018
Fluoxetine dampened stress responses in zebrafish embryos exposed to the drug—and their descendants.
Experimental Drug Relieves Blast-Related PTSD in a Rat Model of Traumatic Brain Injury
Experimental Drug Relieves Blast-Related PTSD in a Rat Model of Traumatic Brain Injury
Viviane Callier | Feb 1, 2018
The compound, BCI-838, is already in human clinical trials as a possible treatment for depression.
Neurometabolic Disorders Could Contribute to Depression
Neurometabolic Disorders Could Contribute to Depression
Ben Andrew Henry | Nov 1, 2016
Impairments in the production of neurotransmitters may lead to depression in some patients, preliminary results show, opening new avenues for research.
Hot Off the Presses
Hot Off the Presses
Bob Grant | Jun 1, 2016
Beyond Biocentrism, The Sting of the Wild, The Birth of Anthropocene, and Ordinarily Well
Zooming In on an Antidepressant Target
Zooming In on an Antidepressant Target
Ruth Williams | Apr 6, 2016
Structural studies reveal how SSRI drugs bind to the human serotonin transporter.
Antidepressant Exerts Epigenetic Changes
Antidepressant Exerts Epigenetic Changes
Anna Azvolinsky | Nov 25, 2015
Molecular markers could aid researchers’ assessment of patient response to the drug.
 
Antidepressant Could Be Prophylactic for Alzheimer’s
Antidepressant Could Be Prophylactic for Alzheimer’s
Rina Shaikh-Lesko | May 14, 2014
An SSRI commonly prescribed to treat depression could help prevent the formation of Alzheimer’s disease-associated amyloid plaques.
Ketamine Alternative Shows Promise
Ketamine Alternative Shows Promise
Abby Olena | Oct 16, 2013
Researchers show that lanicemine is an effective antidepressant without the adverse effects of the related hallucinogenic drug.
Natural Antidepressant Discovered
Sabrina Richards | Jun 25, 2012
A newly recognized chemical factor in the brain, called neuritin, regulates plasticity and may play a role in depression.
Data Diving
Kerry Grens | May 1, 2012
What lies untapped beneath the surface of published clinical trial analyses could rock the world of independent review.