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Psilocybin Relieves Some Treatment-Resistant Depression Cases: Trial
The research has caveats, including side effects and a lack of durability in the benefits of a single dose.
Psilocybin Relieves Some Treatment-Resistant Depression Cases: Trial
Psilocybin Relieves Some Treatment-Resistant Depression Cases: Trial

The research has caveats, including side effects and a lack of durability in the benefits of a single dose.

The research has caveats, including side effects and a lack of durability in the benefits of a single dose.

antidepressants
blue-gloved hands injecting mouse with syringe
Sex of Researcher Influences Ketamine’s Effects in Mice: Study
Shawna Williams | Sep 8, 2022 | 3 min read
The findings likely have implications for animal research far beyond the study of antidepressants.
Molecular structure of fluvoxamine
A Closer Look at the New Fluvoxamine Trial Data
Catherine Offord | Nov 2, 2021 | 8 min read
Authors of a newly published study on the use of an antidepressant for COVID-19 claim the drug greatly reduces hospitalizations and mortality. But some experts question whether that’s really what the data show.
a brain surrounded by pills
Years of Prozac Alter Lipids in Young Monkeys’ Brains: Study
James M. Gaines | Sep 10, 2021 | 4 min read
Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.
Deep Brain Stimulation Improves Depression Symptoms: Study
Catherine Offord | Oct 7, 2019 | 2 min read
The effects of the therapy in a small group of  patients were long-lasting, researchers say, adding to evidence that the approach works for treatment-resistant depression.
Rabbit Study May Hint at Origin of Female Orgasm in Humans
Catherine Offord | Oct 1, 2019 | 2 min read
It could be a throwback to a mechanism that induces ovulation during sex, researchers propose, but not everyone thinks the results can be extrapolated to people.
Antidepressant Approvals Could Herald New Era in Psychiatric Drugs
Bianca Nogrady | Oct 1, 2019 | 9 min read
The FDA has given the green light to the first major new classes of antidepressant therapies in decades, opening up new avenues for therapeutic development.
Forced-Swim Test Criticized as Uninformative, Cruel
Catherine Offord | Jul 22, 2019 | 2 min read
Some researchers and animal rights groups are amplifying their opposition to an assay that measures how long a rodent tries to stay afloat.
How the Brain Changes on Ketamine: A Live Animal Study
Ruth Williams | Apr 11, 2019 | 3 min read
The drug promotes and sustains brain cell connectivity in mice, reversing the effects of chronic stress.
Esketamine, a Treatment for Depression, Receives FDA Approval
Carolyn Wilke | Mar 6, 2019 | 2 min read
The nasal spray to ease intractable depression appears on the US market after decades without novel antidepressant treatments.
Effects of Antidepressants Span Three Generations in Fish
Diana Kwon | Dec 10, 2018 | 4 min read
Fluoxetine dampened stress responses in zebrafish embryos exposed to the drug—and their descendants.
Experimental Drug Relieves Blast-Related PTSD in a Rat Model of Traumatic Brain Injury
Viviane Callier | Feb 1, 2018 | 4 min read
The compound, BCI-838, is already in human clinical trials as a possible treatment for depression.
Neurometabolic Disorders Could Contribute to Depression
Ben Andrew Henry | Nov 1, 2016 | 3 min read
Impairments in the production of neurotransmitters may lead to depression in some patients, preliminary results show, opening new avenues for research.
Hot Off the Presses
Bob Grant | Jun 1, 2016 | 3 min read
Beyond Biocentrism, The Sting of the Wild, The Birth of Anthropocene, and Ordinarily Well
Zooming In on an Antidepressant Target
Ruth Williams | Apr 6, 2016 | 3 min read
Structural studies reveal how SSRI drugs bind to the human serotonin transporter.
Antidepressant Exerts Epigenetic Changes
Anna Azvolinsky | Nov 25, 2015 | 3 min read
Molecular markers could aid researchers’ assessment of patient response to the drug.
 
Antidepressant Could Be Prophylactic for Alzheimer’s
Rina Shaikh-Lesko | May 14, 2014 | 3 min read
An SSRI commonly prescribed to treat depression could help prevent the formation of Alzheimer’s disease-associated amyloid plaques.
Ketamine Alternative Shows Promise
Abby Olena, PhD | Oct 16, 2013 | 2 min read
Researchers show that lanicemine is an effective antidepressant without the adverse effects of the related hallucinogenic drug.
Natural Antidepressant Discovered
Sabrina Richards | Jun 25, 2012 | 3 min read
A newly recognized chemical factor in the brain, called neuritin, regulates plasticity and may play a role in depression.
Data Diving
Kerry Grens | May 1, 2012 | 10+ min read
What lies untapped beneath the surface of published clinical trial analyses could rock the world of independent review.
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