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Microscopy image with blue and red neurons, where red indicates neurons involved in a memory engram
Asthma Drug Helps Mice Retrieve Memories “Lost” to Sleep Deprivation
A study finds roflumilast can reverse sleep deprivation–induced amnesia in mice, hinting at pathways to treating memory loss in people.
Asthma Drug Helps Mice Retrieve Memories “Lost” to Sleep Deprivation
Asthma Drug Helps Mice Retrieve Memories “Lost” to Sleep Deprivation

A study finds roflumilast can reverse sleep deprivation–induced amnesia in mice, hinting at pathways to treating memory loss in people.

A study finds roflumilast can reverse sleep deprivation–induced amnesia in mice, hinting at pathways to treating memory loss in people.

hippocampus
blue-gloved hands injecting mouse with syringe
Sex of Researcher Influences Ketamine’s Effects in Mice: Study
Shawna Williams | Sep 8, 2022 | 3 min read
The findings likely have implications for animal research far beyond the study of antidepressants.
Grey and white stones on a wooden plank
Eight Weeks of Meditation Doesn’t Change the Brain, Study Finds
Natalia Mesa, PhD | May 20, 2022 | 4 min read
Study finds that, contrary to what other research has found, a popular meditation course does not appear to alter brain structure.
The Neuroscience of Motherhood
The Scientist’s Creative Services Team | 1 min read
Robert Froemke and Liisa Galea will discuss the neurological changes that occur during motherhood and their effect on behavior and brain health.
A colorized transmission electron microscope image of an oligodendrocyte (blue) surrounded by cells that it coated in myelin (red outlines).
Brain Fluid from Youngsters Gives Old Mice a Memory Boost
Dan Robitzski | May 11, 2022 | 3 min read
A growth factor found in the cerebrospinal fluid of young mice triggered the proliferation of myelin-making cells when injected into the brains of older mice.
mice on wheel and ground
Exercise-Associated Protein Boosts Brain Function in Mice
Chloe Tenn | Dec 9, 2021 | 5 min read
A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.
Illustration of a brain on a clock with a figure of a man moving the clock arms
Human “Time Cells” Encode, Process Flow of Time
Anne N. Connor | Oct 1, 2021 | 2 min read
Neurons in the hippocampus store information on the timing of experiences in addition to their content, helping to mediate sequential memory recall, a new study shows.
panel depicting mossy fiber synapses and glutamate signaling dynamics
Infographic: Reverse Signaling Between Neurons
Christie Wilcox, PhD | Jun 4, 2021 | 1 min read
So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.
artistic representation of a neuron synapse with light and dark dots passing between two axons
Hippocampal Cell Communication Is Bidirectional: Study
Christie Wilcox, PhD | Jun 4, 2021 | 6 min read
In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.
illustration of a neuron connected to other neurons
Opinion: The Overlooked Power of Inhibitory Neurons
Lauren Aguirre | Jun 1, 2021 | 3 min read
Understanding how the brain coordinates electrical activity could be key to developing more-effective treatments for a variety of brain disorders.
Hippocampal neurons are labeled in blue and purple on a black background
New Role for Leptin: Promoting Synapse Formation in Rat Neurons
Abby Olena, PhD | May 20, 2021 | 3 min read
The hormone, which is well known for regulating appetite, appears to influence neuronal development—a finding that could shed light on disorders such as autism that involve dysfunctional synapse formation.
Dietary Spermidine Boosts Cognition in Insects and Rodents
Ruth Williams | Apr 15, 2021 | 3 min read
Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.
Anesthesia Impairs Memory in Mice
Abby Olena, PhD | Apr 1, 2021 | 3 min read
A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.
Immune Cell and Its Cytokine Control Exploratory Behavior in Mice
Ashley Yeager | Sep 14, 2020 | 5 min read
Gamma delta T cells in the meninges of the brain release a cell signaling molecule that does more than protect mice from microbial pathogens.
Infographic: What Social Isolation Can Mean for the Brain
Catherine Offord | Jul 13, 2020 | 1 min read
People who show low social engagement over long periods of time often show reductions in cognitive function. Studies of the brain may provide clues about this correlation.
Adult-Born Neurons Strengthen Memories While Mice Sleep
Ruth Williams | Jun 4, 2020 | 3 min read
The activation of young brain cells in adult mice is necessary not just for forming memories, but consolidating them during rapid eye movement sleep, a study shows.
memory trace conditioning ca1 hippocampal pyramidal neurons
Unexpected Brain Strategy Links Two Events Separated by Time
Alejandra Manjarrez, PhD | May 13, 2020 | 4 min read
A new study in mice does not find evidence supporting two popular ideas for the mechanism for bridging the temporal time gap between two paired stimuli.
Image of the Day: A Mouse Brain Slice Becomes Art
Amy Schleunes | Apr 1, 2020 | 1 min read
A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.
Image of the Day: Synchronized Neurons
Amy Schleunes | Feb 14, 2020 | 1 min read
Memory formation in mice involves coordinated activity at the cellular level that likely leads to new circuits in the brain.
Image of the Day: Memory Erasure
Amy Schleunes | Feb 12, 2020 | 1 min read
By trimming synapses in the adult mouse hippocampus, microglia help facilitate forgetting.
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