hippocampus

A study finds roflumilast can reverse sleep deprivation–induced amnesia in mice, hinting at pathways to treating memory loss in people.

The findings likely have implications for animal research far beyond the study of antidepressants.

Study finds that, contrary to what other research has found, a popular meditation course does not appear to alter brain structure.

A growth factor found in the cerebrospinal fluid of young mice triggered the proliferation of myelin-making cells when injected into the brains of older mice.

A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.

Neurons in the hippocampus store information on the timing of experiences in addition to their content, helping to mediate sequential memory recall, a new study shows.

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.

Understanding how the brain coordinates electrical activity could be key to developing more-effective treatments for a variety of brain disorders.

The hormone, which is well known for regulating appetite, appears to influence neuronal development—a finding that could shed light on disorders such as autism that involve dysfunctional synapse formation.

Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.

A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.

Gamma delta T cells in the meninges of the brain release a cell signaling molecule that does more than protect mice from microbial pathogens.

People who show low social engagement over long periods of time often show reductions in cognitive function. Studies of the brain may provide clues about this correlation.

The activation of young brain cells in adult mice is necessary not just for forming memories, but consolidating them during rapid eye movement sleep, a study shows.

A new study in mice does not find evidence supporting two popular ideas for the mechanism for bridging the temporal time gap between two paired stimuli.

A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.

Memory formation in mice involves coordinated activity at the cellular level that likely leads to new circuits in the brain.