How a Specific Gut Bacterium May Trigger Type 1 Diabetes

What triggers type 1 diabetes has been difficult to prove, but a bacterium that produces an insulin-like peptide can give mice type 1 diabetes, and infection with the microbe seems to predict the onset of the disease in humans.

Written byDan Robitzski
| 6 min read
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Diabetes, the broad term for a handful of diseases that prevent the body from properly regulating blood sugar levels, was first documented over 3,500 years ago in ancient Egypt—yet experts still aren’t sure exactly how it develops, although scientists are almost certain that there’s no single trigger. Indeed, two primary forms of the condition are already known: types 1 and 2. Type 1 diabetes, which tends to have a more sudden onset, has proven particularly enigmatic, as people can develop the condition at different ages, and unlike type 2, it seems to be more closely linked to genetic and other predispositions than to diet and lifestyle.

Now, research published July 25 in PNAS may have revealed a key piece of the puzzle. The presence of the bacterium Parabacteroides distasonis in the gut microbiome causes type 1 diabetes in a mouse model and seems to predict the onset of the disease ...

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    Dan is an award-winning journalist based in Los Angeles who joined The Scientist as a reporter and editor in 2021. Ironically, Dan’s undergraduate degree and brief career in neuroscience inspired him to write about research rather than conduct it, culminating in him earning a master’s degree in science journalism from New York University in 2017. In 2018, an Undark feature Dan and colleagues began at NYU on a questionable drug approval decision at the FDA won first place in the student category of the Association of Health Care Journalists' Awards for Excellence in Health Care Journalism. Now, Dan writes and edits stories on all aspects of the life sciences for the online news desk, and he oversees the “The Literature” and “Modus Operandi” sections of the monthly TS Digest and quarterly print magazine. Read more of his work at danrobitzski.com.

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