Enhancing Protein Engineering: Site Saturation Variant Libraries
Enhancing Protein Engineering: Site Saturation Variant Libraries
Scientists compared protein engineering with a synthetic library versus error-prone PCR to achieve better variant representation and simpler validation.
Scientists compared protein engineering with a synthetic library versus error-prone PCR to achieve better variant representation and simpler validation.
mutagenesis
Harnessing the Power of Gene Editing for Protein Engineering
Inscripta | Nov 15, 2021 | 1 min read
Targeted, genome-wide CRISPR editing in yeast improves protein yield.
Tardigrades’ List of Super Powers Grows Ever Longer
Ashley Yeager | Jan 1, 2021 | 4 min read
Water bears can survive extreme temperatures, oxidative stress, UV radiation, and more, but as work in climate change biology shows, they’re not invulnerable to everything.
CRISPR Technologies for the New Era of Cell and Gene Therapy
The Scientist | Nov 25, 2020 | 1 min read
Experts will discuss how they use new CRISPR technologies to advance their cell and gene therapy research.
Geneticist Liane Russell Dies
Nicoletta Lanese | Jul 29, 2019 | 2 min read
She conducted innovative research in mutagenesis and teratogenesis related to radiation and chemical exposures, identifying risks to fetuses.
EU Advisor Recommends Regulatory Exemption for Gene Editing
Catherine Offord | Jan 18, 2018 | 2 min read
Crops produced using mutagenic technologies such as CRISPR should generally be exempt from regulatory laws governing GMOs, according to the published opinion.
First Genetic Screen of Pigs Using ENU
Ashley Yeager | Jul 14, 2017 | 3 min read
Using the mutagenic chemical N-ethyl-N-nitrosourea, researchers confirm the role of a gene in a piglet deformity and identify potential models for human diseases.
CRISPR Chain Reaction
Jenny Rood | Mar 19, 2015 | 3 min read
A powerful new CRISPR/Cas9 tool can be used to produce homozygous mutations within a generation, but scientists call for caution.
Lords of the Fly, circa 1910
Dan Cossins | Sep 1, 2013 | 3 min read
In a cramped lab overflowing with fruit flies, Thomas Hunt Morgan and his protégés made the discoveries that laid the foundations of modern genetics.
Fewer Mutations in Tumor Mitochondria
Hayley Dunning | Jun 7, 2012 | 3 min read
Contrary to existing dogma, colon cancer cell mitochondria carry fewer mutations than mitochondria of normal body cells.
Haploid Stem Cells
Tia Ghose | Sep 7, 2011 | 2 min read
Mouse embryonic stem cells that contain half the usual number of chromosomes could be used to untangle gene pathways.