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Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
ABOVE: © ISTOCK.COM, KOTO_FEJA
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Study Nearly Doubles Known Cancer-Linked Mutational Signatures

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

ABOVE: © ISTOCK.COM, KOTO_FEJA

mutation

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Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing
Angie Voyles Askham | Feb 3, 2022
The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.
A close-up image of pale green seeds inside of a green capsule taken by a scanning electron microscope
Essential Genes Protected from Mutations
Dan Robitzski | Jan 25, 2022
Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.
The Scientist Speaks Ep. 16 - At the Breaking Point: Mitochondrial Deletions and the Brain
The Scientist Creative Services Team | Mar 31, 2021
Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.
Rapid antigen tests for SARS-CoV-2
Are Rapid Tests Worse at Detecting Omicron—and Does It Matter?
Catherine Offord | Jan 14, 2022
Anecdotal reports and results from small studies on the diagnostics’ accuracy have prompted questions about the devices’ usage with the new variant, but researchers say more data are needed and emphasize the continued importance of SARS-CoV-2 testing.
two quails
Chromosomal Rearrangement Linked to Less Mobile Quail
Chloe Tenn | Dec 7, 2021
The Scientist interviews evolutionary biologist Carles Vilà about how a large genomic inversion detected in common quail affects the birds’ physical characteristics and migratory behaviors.
Mining Coding Regions with Whole-Exome Sequencing
The Scientist Creative Services Team | Nov 4, 2020
Multiple next-generation sequencing (NGS) techniques offer insights into health and disease.
Isolated Realistic Coronavirus Covid-19 Molecule in a Biological Environment stock photo
Tweak to N Protein Makes Delta Variant More Infectious
Chloe Tenn | Nov 5, 2021
Using a novel lab technique, researchers identified a mutation that allows the virus to insert more genetic material into host cells.
an illustration of the sars-cov-2 spike protein in purple tethered to the viral membrane in dark gray
Spike Protein Deletions Linked to COVID-19 Surges: Preprint
Alejandra Manjarrez | Jun 15, 2021
Researchers find that surges in COVID-19 case numbers are associated with deletions in the SARS-CoV-2 genome in an antigenic site of the spike protein. Some of these mutations are present in vaccine breakthrough infections or reinfections.
No Transgenerational Effects of Chernobyl Radiation Found
Abby Olena | Apr 22, 2021
The genomes of the children of people exposed to fallout from the Chernobyl nuclear accident appear to carry no trace of the incident.
Skin Sheltered from Sunlight Still Gathers UV-Linked Mutations
Abby Olena | Jan 14, 2021
Whole-genome sequencing reveals a wide range of UV-induced DNA changes in human skin cells, and lighter skin collects more mutations, sometimes to “sky high” levels.
South African SARS-CoV-2 Variant Alarms Scientists
Max Kozlov | Jan 5, 2021
An additional mutation in the spike protein of the coronavirus may help it elude antibody recognition, and scientists are investigating if current vaccines will protect against it.
First US Case of UK SARS-CoV-2 Variant Detected
Max Kozlov | Dec 30, 2020
Variant B.1.1.7, though likely more contagious than other strains, does not appear to be more deadly.
UPDATED DEC 21
New SARS-CoV-2 Variant Spreading Rapidly in UK
Max Kozlov | Dec 16, 2020
The significance of the variant remains unclear, but experts remain confident that it will not evade the protection offered by a COVID-19 vaccine.
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Thousands of Coronavirus Infections Stemmed from a Biotech Event
Amanda Heidt | Aug 26, 2020
Officials had initially linked 97 cases to a single conference held by Biogen in February in Boston, but a new study tracking viral genomes suggests the number may be as high as 20,000.
How a Pea Aphid Decides to Make Wings or Not
Viviane Callier | Jun 1, 2020
Wing development in females is environmentally controlled, but in males, an insertion on the sex chromosome appears to dictate whether the insects grow wings, according to a study.
Image of the Day: Tomato Domestication
Amy Schleunes | Mar 30, 2020
Scientists identify a transcription factor that plays a key role in increased fruit size.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Recent Trials for Fragile X Syndrome Offer Hope
Randi Hagerman | Sep 1, 2019
Despite a solid understanding of the biological basis of fragile X syndrome, researchers have struggled to develop effective treatments.
Even Healthy Tissues Carry Clusters of Cells with Mutations: Study
Ashley Yeager | Jun 7, 2019
Most of the genetic alterations are harmless, but some may contribute to cancer.