Exploring How Sequencing and Omics are Shaping Disease Research

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Exploring How Sequencing and Omics are Shaping Disease Research

In this symposium, an expert panel will discuss how sequencing and omics technologies enable unprecedented exploration of health and disease, from genetic disorders to cancer.

| 10+ min read

A Geneticist's Journey From a Lupus Victory to a Murder Case Verdict

A fluorescent imaginal disc from <em >Drosophila </em>larvae on a black background.

| 4 min read

Cancers with an Exceptional Cause

mutation

front view of a green grasshopper with a white and orange face.

Why Do Male Organisms Exist?

Hannah Thomasy, PhD | | 2 min read

Illustration from the epigenetics and the genome infographic

Infographic: How Epigenetic Marks Can Change the Genome

Katarina Zimmer | | 2 min read

Cellular DNA and epigenetics

Do Epigenetic Changes Influence Evolution?

Katarina Zimmer | | 10+ min read

Pink- and purple-stained cells clustered into glands

Phenotypic Variation in Cancer Cells Often Not Due to Mutations

Jef Akst | | 3 min read

Illustration of people dying from the Black Death

Genes that Aided Black Death Survival Linked to Autoimmunity

Jef Akst | | 2 min read

a black wolf and a gray wolf follow a third gray wolf, whose head is tilted back to watch, as they trot through a snowy background, with light colored, barren trees in the background.

Black and Gray Wolf Pairings Stem Disease, Stabilize Population: Study

Katherine Irving | | 4 min read

Illustration of SARS-CoV-2

US Agency to Look into Project on Modified Coronavirus

Catherine Offord | | 3 min read

Illustration of pink and blue DNA molecules.

Historic Adaptations May Now Make Us Susceptible to Disease

Dan Robitzski | | 5 min read

Illustration of a human and Neanderthal skull side by side.

Mutation Linked to Difference Between Human and Neanderthal Brains

Dan Robitzski | | 5 min read

Brown coral in shallow water branching upward with blue fish in front.

Corals Upend Longstanding Idea About Genetic Inheritance

Natalia Mesa, PhD | | 4 min read

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Amanda Heidt | | 2 min read

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Amanda Heidt | | 3 min read

Artist’s rendition of a blue-green DNA double helix, viewed lengthwise from within one end.

Stem Cell Lines Riddled With Undetected Mutations

Dan Robitzski | | 4 min read

Artist’s rendition of multiple <em>Neisseria gonorrhoeae</em>, the bacteria that causes gonorrhea, depicted as two spheres stuck together, each covered in tendrils.

Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study

Holly Barker, PhD | | 4 min read

The Mosaic Brain

Sejal Davla, PhD | | 1 min read

multicolor DNA sequencing gel

Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments

Ryan LayerandThe Conversation | | 5 min read

Illustration of light blue speckled DNA helix on a dark background

Study Nearly Doubles Known Cancer-Linked Mutational Signatures

Jef Akst | | 2 min read

Microscopy image showing patches of magenta and green

Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing

Angie Voyles AskhamandSpectrum | | 3 min read

A close-up image of pale green seeds inside of a green capsule taken by a scanning electron microscope

Essential Genes Protected from Mutations

Dan Robitzski | | 6 min read

Rapid antigen tests for SARS-CoV-2

Are Rapid Tests Worse at Detecting Omicron—and Does It Matter?

Catherine Offord | | 10 min read

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Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A series of rodent experiments showed that even with abundant food and water, personal space is essential to prevent societal collapse, but Universe 25's relevance to humans remains disputed.

A red male cardinal and a brownish female sit on a branch in front of a green background.

Sex Determination: It’s in the Genes—Sometimes

Animals across the tree of life have developed a mind-boggling variety of ways to become male or female.

A group of large animals, some of which are being studied for cancer resistance genes and proteins, are pictured, including a bison, an elephant, a giraffe, a manatee, a zebra, and a whale.

Peto’s Paradox: How Gigantic Species Evolved to Beat Cancer

Scientists dive into the genomes of whales, elephants, and other animal giants looking for new weapons in the fight against cancer.

A cross-section of a mouse brain with staining for NOVA1 and cell nuclei.

Strange Squeaks: A Uniquely Human Gene Alters Mouse “Songs”

A human-specific NOVA1 variant changed mouse vocalizations, potentially providing insights into the evolution of language.

Multimedia

Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Learn how mastering the ins and outs of PCR can accelerate workflows and improve data.

Understanding Disease Through Biomarkers

Understanding Disease Through Biomarkers

Learn how scientists identify and characterize biomarkers for cancer, neurodegenerative diseases, and autoimmune disorders.

A greyscale image of cells dividing.

March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue

Research Resources

Podcasts

Webinars

Videos

Infographics

eBooks

Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Learn how mastering the ins and outs of PCR can accelerate workflows and improve data.

Explore polypharmacology’s beneficial role in target-based drug discovery

Embracing Polypharmacology for Multipurpose Drug Targeting

Polypharmacology allows scientists to explore novel therapeutic purposes for existing drugs and opens new doors to treat multifactorial diseases.

3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Molecular detection technologies help scientists rapidly and reliably find and address ever-evolving pathogens with optimal accuracy and sensitivity.

A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

Discover the key features to consider when selecting a new refrigerator or freezer

Products

Product News

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Gilead’s Capsid Revolution Meets Our Capsid Solutions: Sino Biological – Engineering the Tools to Outsmart HIV

On February 18, 2025, Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir (LEN), a groundbreaking twice-yearly injectable HIV-1 capsid inhibitor for pre-exposure prophylaxis (PrEP).

Stirling Ultracold

Meet the Upright ULT Built for Faster Recovery - Stirling VAULT100™

Slow temperature recovery can threaten the integrity of your work. That’s Stirling Ultracold designed the VAULT100™ to operate at setpoints down to -100°C, so your samples may never be exposed to temperatures above -70°C during a typical door opening.

Chemidoc

ChemiDoc Go Imaging System

The next generation imager from the ChemiDoc Imaging System line. Effortlessly capture gel and western blot images from your benchtop without compromising on sensitivity and precision.

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Evotec Announces Key Progress in Neuroscience Collaboration with Bristol Myers Squibb

• Ongoing strategic partnership advances joint pipeline in neurodegeneration research
• Evotec receives a $20 million payment to further progress research

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