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3D illustration of a lymphocyte in white and green.
A Quest for the Holy Grail of Cancer Targets
Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.
A Quest for the Holy Grail of Cancer Targets
A Quest for the Holy Grail of Cancer Targets

Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.

Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.

neoantigens

Addressing Power and Pitfalls in Machine Learning Neoantigen Prediction
Deanna MacNeil, PhD | Dec 11, 2023 | 4 min read
Researchers honed prediction models and datasets to unlock the potential of deep neural networks in biological applications while avoiding bias.
electron micrograph of grey cancer cell, with two red T cells stuck to the side
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Natalia Mesa, PhD | Mar 29, 2023 | 4 min read
Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.
Neoantigen Prediction for Precision Immunotherapies
Neoantigen Prediction for Precision Immunotherapies 
The Scientist | Jan 12, 2023 | 2 min read
Learn about the tools and resources researchers use to define, discover, and deploy anti-tumor immunotherapies.
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Can mRNA Vaccine Momentum Propel Tumor Immunotherapies?
Aparna Nathan, PhD | Nov 12, 2021 | 4 min read
A guide to mRNA-based cancer vaccines and where they’re headed next
Cancer-Specific Antigens Encoded in “Junk” DNA
Carolyn Wilke | Apr 1, 2019 | 2 min read
Researchers found that allegedly noncoding genetic material carries the instructions for many peptides that may help harness the immune system to fight cancer.
Personalized Cancer Vaccines Show Promise for Melanoma
Jef Akst | Jul 6, 2017 | 2 min read
In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 
Hitting It Out of the Park
Mary Beth Aberlin | Apr 1, 2017 | 3 min read
Cancer can be as evasive and slippery as a spitball, but new immunotherapies are starting to connect.
Contributors
Diana Kwon | Apr 1, 2017 | 3 min read
Meet some of the people featured in the April 2017 issue of The Scientist.
Neoantigens Enable Personalized Cancer Immunotherapy
Stephen P. Schoenberger and Ezra Cohen | Apr 1, 2017 | 9 min read
Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.
Infographic: Targeting Cancer Antigens
Stephen P. Schoenberger and Ezra Cohen | Mar 31, 2017 | 1 min read
Neoantigens may serve as valuable targets for new immunotherapies.
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