NIH
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Prolonged GLP-1 Exposure Remodels Gene Expression in the Pancreas by Flipping a Molecular Switch
Long-term GLP-1 exposure drives phosphorylation of a key protein, resulting in massive changes in gene expression and partial reprogramming of pancreatic beta cells.
Lawnmower-like Enzyme Rewinds Decades of Molecular Aging in Human Tissue
An engineered enzyme cleaved and repaired age-related protein damage in human tissue, which was long thought to be irreversible in a proof-of-concept study.
How the Gut Differentiates Artificial Sweeteners from Sugars
Signals from sweeteners and sugars are relayed from the gut to the brain by different neural pathways, a new study concludes.
Female Brains Wake Up from Anesthesia Differently Than Male Brains
Ketamine anesthesia drives female-specific microglial activity in mice, offering insight about the anesthetic and highlighting the need to study sex as a biological variable.
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Improving rAAV Production for Viral Vector Manufacturing
Explore strategies for improving recombinant adeno-associated virus production in transient HEK293 suspension cultures while maintaining vector quality and supporting scalable viral vector manufacturing.
Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research
Discover how tissue-resident memory T cells develop within the respiratory tract and how these findings are advancing respiratory virus immunity, vaccine research, and high-throughput immune profiling.
