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Infographic showing how neurodegenerative diseases have long been associated with aggregations of apparently toxic proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

Parkinson's
Amyloid plaques on axons of neurons
The Misunderstood Proteins of Neurodegeneration
Catherine Offord | Aug 1, 2022 | 10+ min read
The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.
3D illustration showing neurons inside the brain
Experimental Pill to Treat Parkinson’s Is Safe, Trial Finds
Andy Carstens | Jun 10, 2022 | 2 min read
Testing in animals and lab-grown cells suggests the experimental drug could enhance the function of lysosomes within cells.
Raising the Bar for Biomarkers and Early Diagnostics in Neurodegenerative Disease
Raising the Bar for Biomarkers and Early Diagnostics in Neurodegenerative Disease
Fortis Life Sciences | 3 min read
Identifying novel biomarkers of Parkinson’s disease enables early diagnosis and treatment monitoring.
Histological stain of motor neurons in purple and green
Researchers Use Ultrasound to Control Neurons in Mice
Natalia Mesa, PhD | Feb 9, 2022 | 4 min read
A study shows “sonogenetics” could be a useful new tool in neuroscience and other fields.
pharmacology medicine parkinson's disease dopamine l-dopa levodopa Hornykiewicz obituary
Oleh Hornykiewicz, Who Pioneered Treatment for Parkinson’s, Dies
Amanda Heidt | Jun 18, 2020 | 3 min read
The University of Toronto and University of Vienna pharmacologist developed L-dopa, a precursor to dopamine that remains the most widely used therapy for Parkinson’s disease.
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease
The Scientist Speaks - Lipids Predict a Slippery Path Towards Parkinson’s Disease
Nele Haelterman, PhD | 1 min read
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease.
Into the Light: A Profile of Joanne Chory
Emily Makowski | Mar 1, 2020 | 8 min read
The plant geneticist has revolutionized researchers’ understanding of how light affects plant growth and development, and is engineering plants to combat climate change.
Pelizaeus-Merzbacher disease neural stem cell transplantation
Neural Stem Cell Transplantation Crawls Toward the Clinic
Ashley P. Taylor | Oct 29, 2019 | 9 min read
Several early-stage clinical trials indicate that implanting patients with the cells is safe. But whether they can alleviate neurological problems remains to be seen.
The Best of Cell Biology
Bob Grant | 2 min read
A new eBook compiles recent articles from The Scientist that capture the essence of new conceptual and technological territory being explored on the cellular level.
Is It Time to Rethink Parkinson’s Pathology?
Ashley Yeager | Oct 1, 2019 | 10+ min read
New evidence points to a waste-clearing problem in patients’ cells, rather than the accumulation of protein tangles, as the root cause of the neurodegenerative disease.
Infographic: Is Cellular Waste at the Root of Parkinson’s Disease?
Ashley Yeager | Oct 1, 2019 | 1 min read
Damage to the lysosome, the organelle that removes excess proteins, lipids, and other materials, might be at the root of the disease.
ted dawson alpha-synuclein parkinson's disease model gut vagus nerve dopamine johns hopkins school of medicine
Mouse Model Shows How Parkinson’s Disease Begins in the Gut
Emma Yasinski | Jun 26, 2019 | 3 min read
Johns Hopkins’s Ted Dawson discusses his lab’s demonstration that misfolded α-synuclein can move from the stomach to the brain and cause physical and cognitive symptoms.
a photograph of an older man's upper back
Chemicals on the Skin Could Enable Parkinson’s Detection
Shawna Williams | Mar 20, 2019 | 2 min read
Researchers teamed up with a woman with a keen sense of smell to identify telling differences between healthy people and those with the neurodegenerative disease.
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Katarina Zimmer | Nov 28, 2018 | 6 min read
Since their discovery in 2006, induced pluripotent stem cells have been poised to reprogram regenerative medicine. Twelve years on, here’s how far they’ve come.
Randy Schekman to Leave eLife
Kerry Grens | Aug 19, 2018 | 1 min read
The founding editor-in-chief will redirect his focus to a Parkinson’s organization.
Lindsay Hanford, Geoff B Hall
Trial Launched to Treat Parkinson’s with Reprogrammed Stem Cells
Diana Kwon | Jul 31, 2018 | 1 min read
Surgeons will inject approximately 5 million dopamine-producing progenitor cells into patients’ brains.
Copper Connections
Jim Daley | May 1, 2018 | 2 min read
Researchers initially set out to investigate the relationship between copper homeostasis and the rare Menkes disease, but they also found links to Parkinson’s.
World’s First Commercial iPSC Cell Plant Opens in Japan
Jim Daley | Mar 23, 2018 | 2 min read
The $340 million, 30,000-square-foot center will produce cells for therapeutic applications.
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
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