A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

protein structure
Infographic about SLiMs in SARS-CoV-2 Infection
Infographic: Short Protein Motifs’ Role in SARS-CoV-2 Infection
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022
Known as SLiMs, these stretches of up to 10 amino acids play notable roles in cell biology, including responses to viral invasion.
Spike Structure Gives Insight into SARS-CoV-2 Evolution
Abby Olena | Jul 16, 2020
Researchers demonstrate that the SARS-CoV-2 spike protein is more stable and binds the human ACE2 receptor with much higher affinity than the spike protein of its closest known relative, bat coronavirus RaTG13.
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Probing Antibody Binding to the SARS-CoV-2 Spike Protein
The Scientist Creative Services Team in collaboration with Refeyn
Victor Yin will discuss two single-particle mass analysis methods that shed light on heterogenous, multimeric proteins and their interactions.
an illustration of the coronavirus with a world map in the background
Crowdsourced Protein Simulation Exceeds Supercomputers’ Power
Shawna Williams | Apr 15, 2020
Folding@Home, currently focused on deciphering the workings of SARS-CoV-2, is the first project to have exascale-level computational muscle.
Nobel-Winning Biochemist Paul Boyer Dies
Shawna Williams | Jun 7, 2018
The UCLA researcher was lauded for figuring out how ATP synthase works.
Understanding Cancer Using Cryo-EM
Understanding the Complexity of Cancer with Cryo-EM
The Scientist Creative Services Team and Thermo Fisher Scientific
Explore how researchers use cryogenic electron microscopy (cryo-EM) to identify how mutations affect protein signaling and function through structural or conformational changes.
Unknown Protein Structures Predicted
Ruth Williams | Jan 19, 2017
Metagenomic sequence data boosts the power of protein modeling software to yield hundreds of new protein structure predictions.
Video: Inner Circle
The Scientist Staff | Nov 30, 2016
See an animation that illustrates emerging insights into the inner ring structures of the nuclear pore complex.
Learn How to Accurately Determine Protein Conformation
Focus on Structure to Verify Protein Function
The Scientist Creative Services Team and RedShift Bio
Scientists analyze a therapeutic protein’s secondary structure to confirm drug efficacy and safety.
Fraudulent Paper Pulled
Bob Grant | Jan 5, 2016
Nature retracts a study six years after an investigation found that the protein structures it reported were fabricated.
Getting Back in Shape
Karen Zusi | Dec 1, 2015
Contrary to years of research suggesting otherwise, most aggregated proteins regain their shape and functionality following heat shock.
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Using Nanopores to Sense and Sequence Proteins
The Scientist Creative Services Team
Aleksei Aksimentiev and Stefan Howorka discuss challenges in amino acid sensing with nanopores and approaches to design efficient protein sequencing technology.
Cas9 Proofreads Gene Edits
Karen Zusi | Nov 13, 2015
The gene-editing CRISPR/Cas9 system has three checkpoints to ensure it alters the right section of DNA.
The Handedness of Cells
Kerry Grens | Jun 17, 2015
Actin—the bones of the cell—has a preference for swirling into a counterclockwise pattern.
Scientific Breakthroughs with Cryogenic Electron Microscopy
The Scientist Creative Services Team and Thermo Fisher Scientific
Structures made via cryo-EM give researchers insights into SARS-CoV-2, HIV, neurological disorders, cancer, and more.
Screening Goes In Silico
Carina Storrs | Feb 1, 2015
Computational tools take some of the cost—and guesswork—out of drug discovery.
RNA Puts Proteins in a Headlock
Kerry Grens | May 20, 2014
A noncoding RNA initiates translation by grabbing hold of repressor proteins and restricting their functions.
Transforming Virology Research with Cryo-EM
The Scientist Creative Services Team and Thermo Fisher Scientific
Explore what researchers can do with Cryo-EM
Toxin Evolution
Abby Olena | Jan 16, 2014
Researchers show that scorpion venom toxins are closely related to defensive proteins from venomous insects.