panels depicting mossy fiber synapses and glutamate signaling dynamics

Infographic: Reverse Signaling Between Neurons

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

Infographic: Reverse Signaling Between Neurons

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

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artistic representation of a neuron synapse with light and dark dots passing between two axons

Hippocampal Cell Communication Is Bidirectional: Study

Christie Wilcox, PhD | Jun 4, 2021 | 6 min read

In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.