panels depicting mossy fiber synapses and glutamate signaling dynamics
Infographic: Reverse Signaling Between Neurons
So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.
Infographic: Reverse Signaling Between Neurons
Infographic: Reverse Signaling Between Neurons

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

retrograde signaling
artistic representation of a neuron synapse with light and dark dots passing between two axons
Hippocampal Cell Communication Is Bidirectional: Study
Christie Wilcox | Jun 4, 2021
In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.