A photograph of Christine Guthrie with former students James Umen and Hiten Madhani
RNA Pioneer Christine Guthrie Dies at 77
Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.
RNA Pioneer Christine Guthrie Dies at 77
RNA Pioneer Christine Guthrie Dies at 77

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

ribosomes
Illustration of two weaving proteins 
Fusion with Spider Silk Increases Anticancer Protein’s Stability
Dan Robitzski | Jul 5, 2022
Scientists found that combining the notoriously flimsy anticancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.
Illustration of pink strands of RNA on a blue background
Synthetic RNA Can Build Peptides, Hinting at Life’s Beginnings
Jef Akst | May 12, 2022
Researchers engineered strands of RNA that can link amino acids together, suggesting a way that RNA and proteins may have emerged together to create the earliest forms of life.
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Probing Antibody Binding to the SARS-CoV-2 Spike Protein
The Scientist Creative Services Team in collaboration with Refeyn
Victor Yin will discuss two single-particle mass analysis methods that shed light on heterogenous, multimeric proteins and their interactions.
Steam rises from a blue-gray hot spring, visible beyond a patch of reddish, rocky soil.
Soil Microbes Sacrifice Ribosomes in Response to Warming
Sophie Fessl | Mar 29, 2022
When soil heats up, microbes scale back protein synthesis machinery by making use of higher reaction rates that occur at higher temperatures, a study finds.
illustration of a large purple molecular complex with a strand of orange RNA running through it and red strand emerging from it
Study Reveals Outsize Role of mRNA Region in Tuning Expression
Sophie Fessl | Jan 27, 2022
A new method helps researchers uncover the rules of ribosome recruitment in yeast.
professor photo
Walter Gratzer, Biophysical Chemist and Science Writer, Dies at 89
Chloe Tenn | Nov 23, 2021
His career bridged impactful research in molecular biology and biochemistry with prolific science writing for academic and nonacademic audiences alike.
Fruit flies in a vial
Accurate Protein Production Promotes Longevity
Ruth Williams | Sep 15, 2021
Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.
SARS-CoV-2 Disables Key Components of Human Cells’ Defense System
Catherine Offord | Oct 22, 2020
Researchers detail how viral proteins interact with host RNA to disrupt the cell’s ability to fight back against infection.
ribosomes epithelial to mesenchymal transition cancer progression cell migration
Image of the Day: More Ribosomes
Chia-Yi Hou | May 10, 2019
An increased production of ribosomes may underlie cell migration and relate to cancer metastasis, according to a new study.
translation gene genetics ribosome enhancers knowable magazine
What Does It Look Like to “Turn On” a Gene?
Alla Katsnelson, Casey Rentz, and Knowable Magazine | May 3, 2019
Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.
Ribosomal DNA Can Predict an Animal’s Age
Abby Olena | Feb 14, 2019
A clock constructed of rDNA methylation sites can estimate both chronological and biological age across species.
Those We Lost in 2018
Ashley Yeager | Dec 26, 2018
The scientific community said goodbye to a number of leading researchers this year.
A Nobel Pursuit
The Scientist Staff | Dec 10, 2018
Watch as Nobel laureate Venki Ramakrishnan, who wrote the December Reading Frames essay, discusses Brexit and the importance of sharing scientific insights with the public.
Racing for the Ribosome
Venki Ramakrishnan | Dec 1, 2018
Nobel laureate Venki Ramakrishnan’s new book recounts the tale of researchers striving to understand an ancient molecular machine that is essential for all life.
Thomas Steitz, Biologist and X-Ray Crystallographer, Dies
Ashley P. Taylor | Oct 11, 2018
Steitz determined the atomic structure of the ribosome, work for which he won the 2009 Nobel Prize in chemistry.
How Bacteria in Flies Kill Parasitic Wasps
Shawna Williams | Jul 10, 2017
Ribosome-inactivating proteins from symbiotic bacteria leave their hosts unharmed.
Study: Ribosomes are Functionally Diverse
Diana Kwon | Jun 22, 2017
New research suggests that the cells’ protein factories have preferences for specific messenger RNAs they translate. 
Ribosomal DNA Copy Numbers Decrease in Some Cancers
Abby Olena | Jun 22, 2017
An analysis of human cancer genome projects uncovers a counterintuitive loss of ribosomal gene copies.
Mouse Livers Grow and Shrink Daily
Abby Olena | May 4, 2017
Feeding-fasting rhythms and light-dark cycles direct regular changes in organ and cell size, as well as ribosome number and protein levels.