Synthetic RNA Can Build Peptides, Hinting at Life’s Beginnings

Researchers engineered strands of RNA that can link amino acids together, suggesting a way that RNA and proteins may have emerged together to create the earliest forms of life.

Written byJef Akst
| 2 min read
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RNA has long been thought to be a key molecule in the primordial soup that was Earth a few billion years ago, because it can not only store genetic information but also act as an enzyme—two key functions needed for the development of life as we know it. But whether RNA-based life really existed, what it looked like, and how it evolved into the DNA-, RNA-, and protein-based organisms of today have remained open questions.

Now, a study published yesterday (May 11) in Nature points to the possibility that RNAs may have played a role in building early proteins by simply linking amino acids together. Thomas Carell, an organic chemist at Ludwig Maximilian University of Munich in Germany, and his colleagues created synthetic RNA molecules that could produce peptides up to 15 amino acids long.

The discovery “opens up vast and fundamentally new avenues of pursuit for early chemical evolution,” ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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