An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left).
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
ABOVE: eLife, 10:e69199, 2021
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Amyloid Precursor Protein Linked to Brain Development Mechanisms

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

ABOVE: eLife, 10:e69199, 2021
protein
Photo of Brooke Gardner
Brooke Gardner Probes the Cell’s Peroxisomes
Chloe Tenn | Dec 1, 2021
The University of California, Santa Barbara, cell biologist is investigating the formation and functions of the peroxisome, an organelle which exists in many copies in each cell and can be created, lost, or altered to meet the cell’s metabolic needs.
professor photo
Walter Gratzer, Biophysical Chemist and Science Writer, Dies at 89
Chloe Tenn | Nov 23, 2021
His career bridged impactful research in molecular biology and biochemistry with prolific science writing for academic and nonacademic audiences alike.
Abstract graphene structures
Synthetic Organelles Let Researchers Control Cell Behavior
Catherine Offord | Nov 1, 2021
A technique that reversibly bundles tagged cargo into artificial membraneless compartments gives scientists the ability to switch cell processes on and off.
Illustration showing how engineered cells produce proteins that allow scientists to turn cellular processes on and off
Infographic: One Way to Flip the Cell Behavior Switch
Catherine Offord | Nov 1, 2021
Engineered cells produce proteins that allow scientists to turn cellular processes on and off.
Profile of old man wearing glasses, looking up to the left.
Edmond Fischer, Biochemist and Nobel Laureate, Dies at 101
Lisa Winter | Aug 31, 2021
Fischer was recognized for his work with reversible protein phosphorylation.
Aphid Salivary Gene May Regulate Gall Color
Asher Jones | May 1, 2021
Whether the galls that aphids make on witch hazel leaves are red or green is associated with a gene expressed in the insects’ salivary glands.
Robert “Buzz” Baldwin, Early Expert in Protein Structures, Dies
Jef Akst | Apr 2, 2021
Research by the Stanford University School of Medicine professor revealed how newly formed strings of amino acids fold into complex three-dimensional shapes.
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
Asher Jones | Apr 1, 2021
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
New Screening Approach Reveals Novel Regulators of Microcephaly
Catherine Offord | Jan 1, 2021
Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.
Tardigrades’ List of Super Powers Grows Ever Longer
Ashley Yeager | Jan 1, 2021
Water bears can survive extreme temperatures, oxidative stress, UV radiation, and more, but as work in climate change biology shows, they’re not invulnerable to everything.
How RNAs Called SINEUPs Upregulate Translation
Catherine Offord | Jan 1, 2021
The recently discovered long noncoding RNAs seem to boost the production of specific proteins in the cell by interacting with RNA-binding proteins, researchers find.
Luis Alvarez Aims to Heal Wounds with Tissue-Regenerating “Paint”
Shawna Williams | Jul 13, 2020
The bioactive coating tethers restorative proteins to implanted tissues and fosters new growth, animal studies suggest.