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2022 Top 10 Innovations
2022 Top 10 Innovations
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
2022 Top 10 Innovations
2022 Top 10 Innovations

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

protein
A false color transmission electron microscope micrograph showing the nuclear envelope, the rough endoplasmic reticulum, the nucleus, and the cytoplasm.
New Gene Mutants Identified in Rare Motor Neuron Diseases
Clare Watson | Oct 17, 2022 | 2 min read
The discovery of gene variants in cases of hereditary spastic dysplasia could provide a diagnosis to affected families where no genetic cause could be found before.
Illustration of blue and gray amino acids loosely forming protein
Fungal Cold Adaptation Linked to Protein Structure Changes: Study
Patience Asanga | Sep 20, 2022 | 4 min read
Environmental pressure seems to spawn changes in the intrinsically disordered regions of enzymes in polar yeasts, allowing them to adapt to extreme cold.
A Comprehensive Guide to Proteomics
A Comprehensive Guide to Proteomics
Sejal Davla, PhD | 5 min read
Deconstructing concepts, approaches, and data analysis in proteomics workflows.  
Infographic showing how neurodegenerative diseases have long been associated with aggregations of apparently toxic proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Catherine Offord | Aug 1, 2022 | 5 min read
Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.
The fossil tooth found in the Annamite Mountains in Laos
Ancient Tooth Could Be Clue in Denisovan Migration Mystery
Andy Carstens | May 18, 2022 | 2 min read
The new fossil from Laos helps answer the question of how some people from Oceania carry DNA from the ancient hominin.
Discover how to effectively purify biomolecules with chromatography
Streamlined Purification Workflows for Biomolecule Production
Bio-Rad Laboratories | 1 min read
Researchers optimize chromatography-based workflows to purify biomolecules at scale.
Infographic about SLiMs in SARS-CoV-2 Infection
Infographic: Short Protein Motifs’ Role in SARS-CoV-2 Infection
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022 | 4 min read
Known as SLiMs, these stretches of up to 10 amino acids play notable roles in cell biology, including responses to viral invasion.
Conceptual image of coronavirus, SARS?Cov?2 infects a human cell
Viruses Target Super-Short Protein Motifs to Disrupt Host Biology
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022 | 10+ min read
Only recently appreciated as critical components of cellular functions, unstructured stretches of amino acids called SLiMs are key to viral-host interactions.
Using Single Cell Proteomics to Understand Human Health and Disease
Using Single Cell Proteomics to Understand Human Health and Disease
The Scientist Creative Services Team and 10x Genomics | 1 min read
Miriam Merad and Harrison Specht will discuss how single cell proteomics complement other omics methods to provide insight into disease pathophysiology and treatment.
Illustration of pink strands of RNA on a blue background
Synthetic RNA Can Build Peptides, Hinting at Life’s Beginnings
Jef Akst | May 12, 2022 | 2 min read
Researchers engineered strands of RNA that can link amino acids together, suggesting a way that RNA and proteins may have emerged together to create the earliest forms of life.
An illustration depicting pores on a membrane
DNA Nanopore Sequencing Adapted for Protein Sequence Comparisons
Sophie Fessl, PhD | Feb 14, 2022 | 3 min read
Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore.
Examine Altered Glycobiology in Cancer
Examining Altered Glycobiology in Cancer
The Scientist Creative Services Team and Vector Laboratories | 1 min read
Changes to protein glycosylation play a major role in dictating cancer progression and prognosis, but could they also present biomarkers or therapeutic targets?
Illustration of a DNA-peptide conjugate molecule being pulled through a nanopore in a membrane.
Infographic: Reading Proteins with Nanopores
Sophie Fessl, PhD | Feb 14, 2022 | 1 min read
Adapting DNA nanopore sequencing to peptides allows researchers to identify single amino acid differences.
small striped mammal
Gut Microbes Help Ground Squirrels Endure Hibernation
Alejandra Manjarrez, PhD | Jan 27, 2022 | 4 min read
By breaking down urea, the animals’ gut bacteria recycle nitrogen, which can be then used to build new molecules during prolonged fasting.
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease
The Scientist Speaks - Lipids Predict a Slippery Path Towards Parkinson’s Disease
Nele Haelterman, PhD | 1 min read
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease.
A micrograph of the prion-like state of a protein called Pus4
Protein Mediates Non-Genetic Inheritance of Growth Strategies
Catherine Offord | Jan 4, 2022 | 2 min read
An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.
mice on wheel and ground
Exercise-Associated Protein Boosts Brain Function in Mice
Chloe Tenn | Dec 9, 2021 | 5 min read
A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.
 Optimizing Protein Expression and Production
Technique Talk: Optimizing Protein Expression and Production
The Scientist Creative Services Team | 1 min read
Learn how to efficiently produce large quantities of a biologically active protein.
An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left). Scale bar 50 µm.
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Catherine Offord | Dec 1, 2021 | 2 min read
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
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