A medical professional, wearing light grey scrubs and white laboratory gloves, immunizes a patient, wearing a blue T-shirt, on their right upper arm.
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Since the invention of the first vaccine over two centuries ago, new discoveries have emerged to confer better protection.

smallpox

A transmission electron microscopic image of a tissue section containing variola virus particles, the pathogen responsible for causing smallpox in humans

Opinion: Destroy All Samples of the Smallpox Virus

A two-pronged needle, a glass vial of smallpox vaccine, and a syringe sit on a blue surface.

Smallpox Vaccine Recruits Skin Bacteria to Fight Disease

In one of the only known photos of Abraham Lincoln taken on the day of the Gettysburg Address, Lincoln can be seen seated, hatless, just below and to the right of the flag. Lincoln began developing symptoms of smallpox on the train home to Washington, DC.

Presidential Pox, 1863

black and white electron microscope image showing oval-shaped mature monkeypox virions as well as rounder immature ones

Texas Monkeypox Case Underscores Need for Better Surveillance

Introducing Inoculation, 1721

Epidemiologist Who Helped Eradicate Smallpox Dies

animal vaccinations being given at the Imperial Academy of Medicine in Paris

Bovine Inoculations, circa 1870s

Smallpox Kerfuffle Reveals Biosecurity Problems

CDC Lab Resumes After Safety Lapses

Trending

Kirsty Wright is searching for evidence in a missing persons investigation. She is wearing a blue shirt and glasses. Behind her is dense vegetation and police procedural tape.

How a Forensic Biologist Exposed a DNA Lab Scandal That Shook Australia

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Hands holding an older woman’s hands.

One Gene Influences 75 Percent of Alzheimer’s Disease Cases

A picture of Rohita Roy, a postdoc at Stanford University.

Postdoc Portrait: Rohita Roy

Multimedia

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From Data to Discovery: Omics in Therapeutic Innovation

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Exploring Organoids for Disease Modeling Research

February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

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Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

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Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

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Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

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Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

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Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies