Presidential Pox, 1863

Researchers continue to debate whether US President Abraham Lincoln was coming down with smallpox as he delivered his famous Gettysburg Address, and if he had been immunized.

Written byAnnie Melchor
| 3 min read
In one of the only known photos of Abraham Lincoln taken on the day of the Gettysburg Address, Lincoln can be seen seated, hatless, just below and to the right of the flag. Lincoln began developing symptoms of smallpox on the train home to Washington, DC.
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Seven score and 18 years ago, Abraham Lincoln delivered a brief but consequential speech in Gettysburg, Pennsylvania, the site of the bloodiest battlefield of the American Civil War, where thousands of soldiers had died.

Lincoln was known for his general air of melancholy and bouts of severe depression, but the night after his November 19, 1863 address, he was plagued by something more. According to contemporary accounts, the president’s weakness and dizziness from the day before had worsened into a high fever and a severe headache. A few days later, he developed a rash all over his body, followed by blisters. Although the diagnosis was a mild case of smallpox—suggesting he had preexisting immunity—Lincoln was ordered to quarantine and didn’t resume official duties for almost a month. A more recent analysis suggests Lincoln’s case may have been more severe, and some researchers speculate that his doctor may have intentionally softened ...

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  • black and white photograph of stephanie melchor

    Stephanie "Annie" Melchor got her PhD from the University of Virginia in 2020, studying how the immune response to the parasite Toxoplasma gondii leads to muscle wasting and tissue scarring in mice. While she is still an ardent immunology fangirl, she left the bench to become a science writer and received her master’s degree in science communication from the University of California, Santa Cruz, in 2021. You can check out more of her work here.

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