December 2021 Cover

December 2021

Return of the worms

Researchers are carefully considering the therapeutic potential of helminths

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Features

3D illustration of a tapeworm infestation in a human intestine

Return of the Worms

Top 10 Innovations 2021

2021 Top 10 Innovations

Contributors

Photographs of the December 2021 issue's contributors

Contributors

Editorial

New ideas and imagination Creativity and inspiration Technological innovation.

Innovations that Matter

Speaking of Science

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Ten Minute Sabbatical

Critic at Large

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Opinion: Using Data to Hire High-Impact Faculty

Notebook

MUSCLE CONTROL: Researchers pinpoint how C. elegans (pictured) manages to expel food from its mouth.

The Science Behind How Roundworms Spit

PATH TO TREATMENT: Marley, pictured here with her father, was diagnosed with the rare genetic condition Bachmann-Bupp syndrome a few years ago.

Doctors Treat Girl’s Genetic Disorder with Repurposed Drug

The Literature

False color image of two Caenorhabditis elegans roundworms; blue on a black background

Mitochondrial Stress Is Passed Between Generations

The man-of-war fish (Nomeus gronovii), a species of medusafish, near the tentacles of a siphonophore.

Medusafishes Are Grouped by Shared, Odd Traits: Study

An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left). Scale bar 50 µm.

Amyloid Precursor Protein Linked to Brain Development Mechanisms

Scientist to Watch

Photo of Brooke Gardner

Brooke Gardner Probes the Cell’s Peroxisomes

Bio Business

DNA

In Editing RNA, Researchers See Endless Possibilities

Reading Frames

Great Minds Don't Think Alike

Opinion: Bridging the Intellectual Divide

Foundations

In one of the only known photos of Abraham Lincoln taken on the day of the Gettysburg Address, Lincoln can be seen seated, hatless, just below and to the right of the flag. Lincoln began developing symptoms of smallpox on the train home to Washington, DC.

Presidential Pox, 1863

Infographics

How C. elegans Transmit Stress Signals to Offspring

Infographic: How C. elegans Transmit Stress Signals to Offspring

December 2021 - Gut Guests - Infographic

Infographic: How Worms that Reside in the Gut Could Influence Health

Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).

Infographic: RNA Editing Approaches

Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

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Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
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An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

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Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

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Thermo Scientific X and S Series General Purpose Centrifuges

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VANTAstar Flexible microplate reader with simplified workflows

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