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Two sister cells are seen in the foreground, while individual cells are seen behind them on a blue background.
Sister Cells Reveal Cancer’s Fate
A new method traces treatment resistant cells and predicts drugs that can make them more susceptible to cancer therapy.
Sister Cells Reveal Cancer’s Fate
Sister Cells Reveal Cancer’s Fate

A new method traces treatment resistant cells and predicts drugs that can make them more susceptible to cancer therapy.

A new method traces treatment resistant cells and predicts drugs that can make them more susceptible to cancer therapy.

tumor heterogeneity

Image of spatial transcriptomic spots superimposed onto a stained tissue section.
Poor Cancer Prognosis Associated with a Transcriptional Signature
Charlene Lancaster, PhD | Sep 11, 2023 | 4 min read
Researchers connect a tumor’s leading edge transcriptional profile to poor survival outcomes across cancer types. 
A colorful image of a tumor
Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy
Chengsheng Wu, David Cheresh, and Sara Weis; The Conversation | Jan 17, 2023 | 5 min read
Research into how pancreatic tumors adapt to stress could lead to a new treatment approach.
Understanding How Single Cell Evolution Drives Tumor Complexity
Understanding How Single Cell Evolution Drives Tumor Complexity
The Scientist | 1 min read
Andris Abramenkovs and Mark Lynch will discuss how to overcome challenges obtaining high-definition genomic data from single cells.
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
A purple-stained section of an invasive breast cancer growth. The dark purple non-fatty tissue takes up the majority of the frame, and pale purple circular tumors grow in ducts in the bottom left.
Harboring Hard and Soft Cells Lets Tumors Grow and Metastasize Simultaneously
Katherine Irving | Oct 17, 2022 | 4 min read
Islands of rigid cells within a matrix of soft ones allow tumors to be both solid and fluid, granting them toughness without losing the ability to break apart.
Revealing the Complexities of Cancer with Single-cell RNA Analysis
The Scientist | 1 min read
Download this eBook to learn how single-cell analysis identifies subpopulations of tumor cells!
Photograph of Humsa Venkatesh
Humsa Venkatesh Probes Cancer’s Grip on the Brain
Maddie Bender | Aug 15, 2022 | 3 min read
At Brigham and Women’s Hospital, the cancer biologist is combining research into the tumor microenvironment with the principles of neuroscience to tease apart how cancers grow—and how to stop them.
Diffuse star-like shapes with regions in purple, green, and both colors overlapped.
Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez, PhD | Mar 25, 2022 | 5 min read
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
Stem Cells in Human Teeth Follow the Rules of Their Environment
Roni Dengler, PhD | Feb 7, 2022 | 2 min read
How stem cells in human teeth respond to different environmental conditions offers clues for regenerative medicine.
CAR T cells, oncolytic virus, CD19, mouse model, solid cancer, liquid cancer, tumor, immune response, immunotherapy, T cell, treatment
Immunotherapy Combo Reduces Solid Tumors in Mice
Amanda Heidt | Sep 9, 2020 | 5 min read
When tumor cells are infected with an oncolytic virus carrying a modified CD19 gene, they become targets for CAR T cells engineered to recognize this molecular marker.
Infographic: Researchers Take Aim at Cancer Evolution
Catherine Offord | Apr 1, 2020 | 2 min read
Strategies to trick, manipulate, and direct the evolution of tumors
Cancer Researchers Use Evolution to Target Drug Resistance
Catherine Offord | Apr 1, 2020 | 10+ min read
New therapeutic approaches in oncology aim to manipulate or block cancer’s adaptation to treatment.
The Scientist on the Pulse, April 23
Kerry Grens | Apr 23, 2015 | 1 min read
Hot topics in cancer research from the annual meeting of the American Association for Cancer Research
To Each His Own
Mary Beth Aberlin | Apr 1, 2015 | 3 min read
Cancer treatment becomes more and more personal.
Opinion: Overcoming Cancer’s Complexities
Daniel S. Kapp, David Rubenson, and Beverly Mitchell | Apr 11, 2014 | 4 min read
Considering “targeted therapeutics” in the face of intra-patient heterogeneity. 
Up, Up, and Array
Megan Scudellari | Apr 1, 2013 | 8 min read
By scrutinizing gene expression profiles instead of individual oncogenes, Todd Golub launched a powerful platform for diagnosing, classifying, and treating cancer.
Cancer Clinical Trials of Tomorrow
Tomasz M. Beer | Apr 1, 2013 | 4 min read
Advances in genomics and cancer biology will alter the design of human cancer studies.
Cancer More Diverse than Its Genetics
Ruth Williams | Dec 13, 2012 | 3 min read
Tumor cells can exhibit different behaviors despite being genetically indistinguishable.
An Epi Phenomenon
Karen Hopkin | Dec 1, 2012 | 9 min read
While exploring the genetics of a rare type of tumor, Stephen Baylin discovered an epigenetic modification that occurs in most every cancer—a finding he’s helping bring to the clinic.
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