Fluorescence microscopy image of a human small intestine organoid stained with Ki67 and EpCAM antibodies and DAPI (scale bar represents 100 micrometers).

| 3 min read

Capturing Cancer Complexities with Tumor Organoid Cultures

Choosing the right 3D culture components and validation steps helps researchers unlock accurate, reproducible, and relevant insights into cancer biology.

Images of tumor organoids acquired using high-speed live cell interferometry.

| 3 min read

Evaluating Tumor Heterogeneity with a High Throughput Pipeline

Two sister cells are seen in the foreground, while individual cells are seen behind them on a blue background.

| 4 min read

Sister Cells Reveal Cancer’s Fate

tumor heterogeneity

Image of spatial transcriptomic spots superimposed onto a stained tissue section.

Poor Cancer Prognosis Associated with a Transcriptional Signature

Charlene Lancaster, PhD | | 4 min read

Understanding How Single Cell Evolution Drives Tumor Complexity

Understanding How Single Cell Evolution Drives Tumor Complexity

Available on Demand

A colorful image of a tumor

Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy

Chengsheng Wu,David Cheresh,Sara WeisandThe Conversation | | 5 min read

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Phenotypic Variation in Cancer Cells Often Not Due to Mutations

Jef Akst | | 3 min read

A purple-stained section of an invasive breast cancer growth. The dark purple non-fatty tissue takes up the majority of the frame, and pale purple circular tumors grow in ducts in the bottom left.

Harboring Hard and Soft Cells Lets Tumors Grow and Metastasize Simultaneously

Katherine Irving | | 4 min read

Photograph of Humsa Venkatesh

Humsa Venkatesh Probes Cancer’s Grip on the Brain

Maddie Bender | | 3 min read

Explore single cell and spatial methods for studying cancer biology

Analyzing Multiple Dimensions of Cancer Biology

10x Genomics | | 1 min read

Diffuse star-like shapes with regions in purple, green, and both colors overlapped.

Tumor Cells on Brink of Death May Trigger Metastasis

Alejandra Manjarrez, PhD | | 5 min read

Stem Cells in Human Teeth Follow the Rules of Their Environment

Roni Dengler, PhD | | 2 min read

Page 1 of 2 - 24 Total Items

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The Biggest Breakthroughs in Cell Biology in 2025

From microglia reprogramming to immune cell-based diagnostics, 2025 was a big year for breakthroughs in cell biology.

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A series of rodent experiments showed that even with abundant food and water, personal space is essential to prevent societal collapse, but Universe 25's relevance to humans remains disputed.

A brown dog stares at a spoon of peanut butter in front of its face with wide eyes.

Why Do Dogs Love Peanut Butter?

The reason dogs beg, sit, stay, and shake for peanut butter could be both evolutionarily wired and learned behavior.

Gollum, the extremely territorial character from The Lord of the Rings, famous for his line, “My precious,” sits on a rock, looking up.

The Gollum Effect: 44 Percent of Scientists Report Territorial Research Experiences

Survey data showed that hoarding research topics and resources, termed the Gollum effect, has a lasting impact on trainees and perpetuates a toxic research culture.

Multimedia

Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Explore the latest in cell culture supplies, from tried and tested classics to cutting-edge innovative products.

Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Explore the latest in cell culture supplies, from tried and tested classics to cutting-edge innovative products.

December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.

December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue

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Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Explore the latest in cell culture supplies, from tried and tested classics to cutting-edge innovative products.

Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Explore the latest in cell culture supplies, from tried and tested classics to cutting-edge innovative products.

Abstract wireframe sphere with colorful dots and connecting lines representing the complex cellular and molecular interactions within the tumor microenvironment.

Exploring the Inflammatory Tumor Microenvironment

Within the tumor microenvironment, networks of cells and molecular signals form a dynamic landscape that drives disease progression.

An image of a DNA sequencing spectrum with a radial blur filter applied.

A Comprehensive Guide to Next-Generation Sequencing

Individual NGS methods come with their own pros and cons, but automation optimization solutions exist for all NGS workflows.

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BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS)

This partnership will enable both companies to reach a broader range of customers, including those with more complex and specialized workflows

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Enter Our 2026 Top Innovations Contest

Submit a cutting-edge product or technology for the chance to be recognized as one of The Scientist’s 2026 Top Innovations.

Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging

Biotium's new TyraMax™ Amplification Dyes and Kits are available with the widest selection of colors for spatial analysis

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

Ten-year Agreement to Provide a Secure, AI-enabled Forensic Laboratory Information Management System Supporting DHS Forensic, Scientific, and Testing Services