Telomere Biology

Edited by: Ricki Lewis D. Broccoli, J.W. Young, T. de Lange, "Telomerase activity in normal and malignant hematopoietic cells," Proceedings of the National Academy of Sciences, 92:9082-6, 1995. (Cited in 95 publications through June 1997) Comments by Titia de Lange, Rockefeller University UNEXPECTED FINDING: Titia de Lange's lab at Rockefeller University used a sensitive assay to detect telomerase activity in noncancerous cells. A paper that reports an unexpected finding is destined to be hi

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Edited by: Ricki Lewis
D. Broccoli, J.W. Young, T. de Lange, "Telomerase activity in normal and malignant hematopoietic cells," Proceedings of the National Academy of Sciences, 92:9082-6, 1995. (Cited in 95 publications through June 1997)

Comments by Titia de Lange, Rockefeller University


UNEXPECTED FINDING: Titia de Lange's lab at Rockefeller University used a sensitive assay to detect telomerase activity in noncancerous cells.
A paper that reports an unexpected finding is destined to be highly cited, and so it is for this 1995 article from the cell biology and genetics laboratory at the Rockefeller University, headed by Titia de Lange. She and colleagues Dominique Broccoli and Jim Young detected telomerase activity in normal, noncancerous cells.

The telomeres, or chromosome tips, of human somatic cells shrink with each cell division. In germline cells such as sperm and in malignant cells, chromosome length is maintained by telomerase, an enzyme that includes a short ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Ricki Lewis

    This person does not yet have a bio.

Published In

Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
Collage-style urban graphic of wastewater surveillance and treatment

Putting Pathogens to the Test with Wastewater Surveillance

An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide