The importance of variation and evolution of gene expression during complex developmental processes is still relatively poorly understood. In an Advance Online Publication in Nature Genetics, Scott Rifkin and colleagues from Yale University, USA, describe a comparative genomics study to characterize inter-species differences in gene expression during Drosophila metamorphosis (Nature Genetics, doi;10.1038/ng1086, January 27, 2003).

They used microarrays to measure genome-wide developmental changes in 12,866 genes at the onset of metamorphosis in four inbred strains of Drosophila melanogaster and strains of D. simulans and D. yakuba. Around 27% of genes differed significantly in the extent of developmental change between at least two lineages. Only about 1,000 genes changed significantly in all lineages.

Rifkin et al. found that changes in the expression of genes encoding key transcription factors are relatively stable, whereas their downstream target genes show greater evolutionary changes in expression.

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Join for free todayAlready a member?Login Here