Thyroid-stimulating autoantibodies preferentially recognize the free A subunit, not the thyrotropin holoreceptor, in Graves thyrotoxicosis.
In Graves disease, thyroid-stimulating autoantibodies activate the thyrotropin receptor (TSHR), leading to increased thyroid hormone secretion and clinical thyrotoxicosis, but the exact molecular interactions are not know. In 15 July
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These results "provide evidence that TSAb's in Graves disease preferentially recognize the free A subunit and not the TSH holoreceptor," concluded the authors. "This observation supports the ...
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