Inactivation of tumor suppressor genes is an essential stage in the development of human cancer but the extent of the involvement of epigenetic silencing and hypermethylation in this process remains unclear. In April 4 Nature, Ina Rhee and colleagues from Johns Hopkins University School of Medicine, show that two enzymes (DNMT1 and DNMT3b) cooperate to silence genes and maintain DNA methylation in human cancer cells.Rhee et al. worked on a colorectal cancer cell line and observed that only genet
Inactivation of tumor suppressor genes is an essential stage in the development of human cancer but the extent of the involvement of epigenetic silencing and hypermethylation in this process remains unclear. In April 4
Rhee
These results "establish that methylation is essential for silencing tumor suppressor genes in human cancer cells. It will be of ...
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