Most of the physiological and behavioral processes in mammals exhibit a daily rhythm, maintained by a central 'clock' in the brain, but the molecules that connect the brain clock with the body remain unknown. In 23 May Nature, Michelle Cheng and colleagues from University of California, Irvine, show that prokineticin 2, a cysteine-rich secreted protein, functions as an output molecule from the suprachiasmatic nucleus to the rest of the body.Cheng et al. studied mice under dark and light conditio
Most of the physiological and behavioral processes in mammals exhibit a daily rhythm, maintained by a central 'clock' in the brain, but the molecules that connect the brain clock with the body remain unknown. In 23 May
Cheng
These results "offer enormous scope for intervention ...
In mammals, intracellular clocks begin to tick within days of fertilization.
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