Mammalian peripheral tissues have circadian clocks that keep time by generating daily rhythms of transcription. In an Advanced Online Publication in Nature, Kai-Florian Storch and colleagues at Harvard Medical School, report a comparative analysis of the circadian variation in gene expression in mouse liver and heart (Nature 2002, DOI 10.1038/nature744).Storch et al. used oligonucleotide microarrays to follow changes in the expression of over 12,000 genes over a 24 hour period. They applied a fi
Mammalian peripheral tissues have circadian clocks that keep time by generating daily rhythms of transcription. In an Advanced Online Publication in
Storch
When they compared the sets they found very little overlap, with only 52 genes being common to both tissues. Gene ontology analysis ...
In mammals, intracellular clocks begin to tick within days of fertilization.
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