Activating a subset of myelin basic protein (MBP)-specific T cells that have escaped tolerance induces autoimmune encephalomyelitis in mice. This is considered a disease model for multiple sclerosis. Escaping tolerance is believed to result from sequestration of MBP within immune-privileged sites that allow only limited lymphocyte trafficking. In the April Immunity Eric Huseby and colleagues from University of Washington, Seattle show that escaping tolerance is also an age dependent mechanism.Hu
Activating a subset of myelin basic protein (MBP)-specific T cells that have escaped tolerance induces autoimmune encephalomyelitis in mice. This is considered a disease model for multiple sclerosis. Escaping tolerance is believed to result from sequestration of MBP within immune-privileged sites that allow only limited lymphocyte trafficking. In the April
Huseby
These results suggest that genetic variation in factors modulating expression of MBP or ...
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