AMLWIKIMEDIA COMMONS, PEIR DIGITAL LIBRARY
1. Blocking epigenetics to stop cancer
A chromatin-regulation protein controls the epigenetic reprogramming that drives acute myeloid leukemia (AML). Knockdown of this protein, which normally upregulates the oncogene Myc, selectively killed the AML cells, and suggests a new target for treating this aggressive disease.
J. Zuber et al., "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia," Nature, doi: 10.1038/nature10334, 2011. Free F1000 Evaluation
Inflammasomes activate innate immune inflammation, but how these proteins were activated was poorly understood. Now researchers discover a family of proteins called NAIPs, previously thought to play a non-essential role, which act as sensors that specifically detect several bacterial components and activate the inflammasome.
E.M. Kofoed, R.E. Vance, “Innate immune recognition of bacterial ligands by ...
