Top 7 in Immunology

A snapshot of the most highly ranked articles in immunology and related areas, from Faculty of 1000

Written byEdyta Zielinska

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AMLWIKIMEDIA COMMONS, PEIR DIGITAL LIBRARY

1. Blocking epigenetics to stop cancer

A chromatin-regulation protein controls the epigenetic reprogramming that drives acute myeloid leukemia (AML). Knockdown of this protein, which normally upregulates the oncogene Myc, selectively killed the AML cells, and suggests a new target for treating this aggressive disease.

J. Zuber et al., "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia," Nature, doi: 10.1038/nature10334, 2011. Free F1000 Evaluation

2. Inflammasome helpers

Inflammasomes activate innate immune inflammation, but how these proteins were activated was poorly understood. Now researchers discover a family of proteins called NAIPs, previously thought to play a non-essential role, which act as sensors that specifically detect several bacterial components and activate the inflammasome.

E.M. Kofoed, R.E. Vance, “Innate immune recognition of bacterial ligands by ...

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Meet the Author

Edyta Zielinska
Edyta Zielinska was a senior editor at The Scientist from 2007 to 2013, where she worked closely with scientific illustrators to develop accompanying graphics to illuminate complex concepts.
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