Toward Eliminating Poliovirus—In the Lab

As the world inches closer to polio eradication, laboratories studying the virus will have to bolster biosafety standards. Eventually, most will need to stop working with the pathogen entirely.

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Electron micrograph of poliovirusWIKIMEDIA, CDCIn September, the Global Polio Eradication Initiative (GPEI) declared type 2 poliovirus eradicated. This long-awaited statement officially confirmed what polio researchers and global public health officials had known for more than a decade: one of the triumvirate of polioviruses was no longer a threat. The last case of type 2 poliovirus was diagnosed in Northern India in 1999.

The announcement also set in motion a critical component of the GPEI’s Poliovirus Eradication Endgame Strategic Plan. Among other things, public health officials are planning to stop using oral polio vaccine against type 2 poliovirus in April 2016. To reduce risk of accidental release, all laboratories that stock type 2 poliovirus—both the wild-type and vaccine virus—will need to destroy the virus soon after that date, or adopt stricter standards for handling it.

Containment of type 2 poliovirus, “really is a step forward to containment of type 1 and 3,” said Walter Dowdle, a consultant to the Task Force for Global Health and former deputy director of the US Centers for Disease Control and Prevention (CDC).

This transition for handling laboratory stocks of type 2 poliovirus ...

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