 Zebrafish |
Zebrafishes are the only viable candidate for large-scale vertebrate mutagenesis screens akin to those done in C. Elegans and Drosophila --a task that's usually too expensive in the mouse.
In mice, so-called reverse genetics is utilized; scientists perform knockout mutations on a known gene of interest and then study the resulting mutant animals. In zebrafish, researchers, using forward genetics, first randomly mutate genes and then attempt to understand the function of those genes. The procedure allows investigators to explore much more of the unknown or poorly understood parts of the genome in ...
