45,000 Year-Old Bone Sequenced

The oldest human genome to have been sequenced came from a leg bone preserved in Siberia.

kerry grens
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The Ust'-Ishim femur. BENCE VIOLA, MPI EVAAt the end of the Middle Paleolithic, a man died in Siberia. Now, his DNA has come back to life some 45,000 years later. Reporting in Nature this week (October 22), scientists have sequenced the oldest human genome, taken from a thigh bone found along the banks of the Irtysh river in Siberia.

“We were actually so amazed [by the age of the bone], we actually had it dated even twice, to make sure,” Svante Pääbo, the senior author of the study and the director of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, told NPR.

The bone helps to date early human migrations. “There is a dispute as to when that ‘Out of Africa’ event happened and this fossil helps to look at that. It is close to the time I think that modern humans exited from Africa and gave rise to the populations in the rest of the world. I think that exit happened 60,000 years ago,” Chris Stringer of the Natural History Museum in London told BBC News.

A few interesting finds came ...

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Meet the Author

  • kerry grens

    Kerry Grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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