A Movable Defense

In the evolutionary arms race between pathogens and hosts, genetic elements known as transposons are regularly recruited as assault weapons for cellular defense.

Written byEugene V. Koonin and Mart Krupovic
| 11 min read

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JUMPERS: Transposable elements, which make up as much as 90 percent of the corn genome and are responsible for the variation in kernel color, may also be at the root of diverse immune defenses.COMPOSITE IMAGE. © ARINA P. HABICH/SHUTTERSTOCK.COM; © ISTOCKPHOTO.COM/JAUHARI1

Researchers now recognize that genetic material, once simplified into neat organismal packages, is not limited to individuals or even species. Viruses that pack genetic material into stable infectious particles can incorporate some or all of their genes into their hosts’ genomes, allowing remnants of infection to remain even after the viruses themselves have moved on. On a smaller scale, naked genetic elements such as bacterial plasmids and transposons, or jumping genes, often shuttle around and between genomes. It seems that the entire history of life is an incessant game of tug-of-war between such mobile genetic elements (MGEs) and their cellular hosts.

MGEs pervade the biosphere. In all studied habitats, from the oceans to soil to the human intestine, the number of detectable virus particles, primarily ...

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