The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.

A comparison of interferon-related genes across 20 primate genomes reveals differences in the speed at which they evolve and new targets for antiviral discovery efforts.

A recent study sheds light on a previously unknown mechanism for fending off the pathogen, and potentially other viruses as well.

A pathway involved in the adaptive immune system, a relative newcomer in the world of pathogen defense, may have a more ancient role in protecting cells from invading viruses.

Far from being inert fat-storage depots within cells, these lipid-loaded organelles recruit immune proteins and block bacterial growth.

The rare complication known as multisystem inflammatory syndrome in children (MIS-C) differs from both Kawasaki disease and severe adult cases of COVID-19, a study finds.

These antiviral proteins are produced by the body as a natural defense against viral infections and synthetic interferons might help prevent or treat the beginning stages of SARS-CoV-2 infection.

The viral protein known as ORF3b limits the induction of the type I interferon response, which typically alerts other immune system components to the presence of a virus, in cultured cells.

This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.

Human natural killer cells, previously considered not to participate in adaptive immunity, remember viral antigens after initial exposures, according to a new study.

In CRISPRed fruit flies that lack certain antimicrobial peptides, bacterial infections flourish, as revealed by fluorescent markers.

The antimicrobial drug neomycin protects mice from some viral infections, complicating the picture of the relationship between antibiotics and susceptibility to viruses.

Interbreeding with Neanderthals appears to have reintroduced genetic sequences related to innate immunity that had been lost as humans migrated out of Africa. 

Certain immune cells surrounding the organ appear to block viral entry.

The maternal gut microbiome guides neo- and postnatal immune system development, a mouse study shows. 

Endogenous retroviruses in the human genome can regulate genes involved in innate immune responses.

Dictyostelium discoideum produce extracellular nets that can kill bacteria, just as phagocytes in people and other higher animals do, according to a study.

Neanderthals and Denisovans contributed innate immune genes to modern humans, scientists show.

When influenza invades the mouse respiratory tract, neutrophils guide the subsequent T-cell attack on infected tissue, scientists show.