Articles by Cathy Holding

'Domesticated' gene may have helped originate placenta in mammals

Model points to importance of polymerase activity in species jump

RNA interference (RNAi) takes place in the nuclei of human cells, according to a group from the University of Massachusetts Medical School.

US group says RNA interference takes place in the nucleus, but one expert is unconvinced

By exploiting a malaria parasite's "Achilles heel," researchers in Germany say a transgenic whole-organism vaccine for humans may be possible.

Study shows promise for 'ecological' approach, but other researchers raise questions

Mouse needs G-protein-coupled receptor to keep its eggs fresh, according to study

Genetically modified parasite induces immunity in rodents, but some doubt use in humans

Findings on Fugu gene splicing could help scientists develop pufferfish transgenes for mammalian cells, say researchers at Massachusetts Institute of Technology.

Cell line study shows miR-375 regulates the late stages of insulin secretion

Study uncovers mechanism of histone monoubiquitylation and gene silencing

Understanding how mammal splicing enhancers differ from fish makes Fugu more useful

A genetically modified grass has passed a RoundUp-resistance transgene on to a related species growing 14 km away and to wild-growing plants of the same species 21 km away, according to a group from the US Environmental Protection Agency. A novel sampling method, employing widespread sentinel plants placed at different locations, found evidence of gene flow from transgenic bent-grass (Agrostis stolonifera) into the related species, Agrostis gigantea.But, there was no evidence that the gene cross

THE KEYS TO CAGE© 2003 National Academy of Sciencesand its competitors are a 5' cap-trapping step and a class II restriction enzyme (MmeI), which cleaves DNA 20/18 bp downstream of the recognition site to create the sequence tag. (Reprinted from T. Shiraki, Proc Nat Acad Sci, 100:15776–81, 2003.)Serial analysis of gene expression (SAGE) has been used extensively to map and quantify transcripts in different tissues. But the technique, which extracts short oligos (14–21 bp long) f

Genome revised down to under 25,000 genes; failings of whole genome shotgun revealed