In the years since they were first developed, microarrays have been applied to an extraordinary range of situations.

In June, Derek Lowe got some data.

Pursuit of genetic factors involved in a leading cause of blindness points to complement pathway

In theory, aptamers can specifically bind and modulate the activity of any protein for which they're designed.

Bert Myers/Photo Researchers Inc.This past December, the US Food and Drug Administration approved Prialt, Elan Corporation's synthetic version of a peptide from the venomous sea snail Conus magus. The drug, ziconotide, is the first of its kind and appears to alleviate severe pain by blocking N-type Ca+ channels.Ziconotide is designed from one of about 100 pharmacologically active compounds in C. magus. And this undersea combinatorial chemist is only one of approximately 500 Conus species. Resear

Peptide mimetics are becoming increasingly popular pipeline leads for pro-apoptotic cancer drugs.

Marine threespine sticklebacks haven't morphologically changed in an estimated 10 million years, but their freshwater offshoots show no signs of slowing down. These 5-cm-long, freshwater fish have undergone a recent evolutionary change, variably losing their calcified body armor and retractable pelvic and dorsal spines. Remarkably, isolated marine and freshwater sticklebacks can be hybridized in the laboratory, a fact that is allowing researchers to analyze the genetics behind their natural dive

Worm and human antiapoptotic genes protect tomatoes from cold temperatures and infection

HALF FULL, HALF EMPTY, OR ...© 2004 AAASAfter each neurotransmitter release, MK801, an open-channel blocker that can only block a channel that has been activated, decreases initial current (which has been normalized for wild type and mutant cells). In the colocalization model, VGLUT1 and VGLUT2 occupy the same vesicles filling them partially. The commingling model proposes that transporters occupy distinct vesicles in the same synapse. The segregation model proposes that the transporters ar

Drosophila Hmx gene directs development of mouse inner ear, an organ flies don't possess

Inhibition of peptidase CD26 found to increase efficiency of procedure in mice

Nuclear transfer of a melanoma cell nucleus reveals epigenetic changes to be reprogrammable