Ian Le Guillou Author Profile | The Scientist Magazine®

bace1 alzheimer's disease gga3 axon neuron

Alzheimer’s-Linked Mutation Causes Blockages in Neurons

Ian Le Guillou | Nov 20, 2020 | 3 min read

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

tau pet scan tracer tauopathy alzheimer's disease progressive supranuclear palsy corticobasal degeneration pick's disease frontotemporal lobal degeneration ftd alzheimer's disease neurodegeneration

New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias

Ian Le Guillou | Oct 29, 2020 | 3 min read

An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.

amyloid-beta amyloid plaque alzheimer's disease coarse-grained neurodegeneration ab40 ab42

Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease

Ian Le Guillou | Sep 28, 2020 | 4 min read

These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.