Addictive Research 20 years ago, scientists got hooked on a single transcription factor that responds to a number of drugs of abuse. Will their work lead to treatments? By Kerry Grens Related Articles 1 When the drug was removed, the enzyme's activity spiked, which the authors interpret as a cellular withdrawal from dependency: "This phenomenon can be likened to the abstinence syndrome in animals." "You're profoundly altering the nature of nerve cells." -E

CREB, alcohol, and anxiety By Kerry Grens ARTICLE EXTRAS 1 Another quality of the rats interested Subhash Pandey of the University of Illinois at Chicago. "When they drink alcohol," Pandey says, "their anxiety disappears." Pandey wanted to find out what was responsible. He turned to CREB and one of its targets, neuropeptide Y (NPY), a potent, endogenous anxiolytic compound. Heilig, when he was a postdoc with George Koob at the Scripps Research Institute, had shown that N

Two customers who deposited several thousand dollars for a hypoallergenic cat from a company I linkurl:investigated;http://www.the-scientist.com/article/display/39383/ earlier this year have written to The Scientist saying they were denied kitties, and got their money back. Lynne Butler, a mathematics professor at Haverford College, received a $5,900 wire transfer from Allerca, Inc after she posted a linkurl:comment;http://www.the-scientist.com/blog/display/52947/ on our website that she had n

Two studies find adult pancreatic cells maintain islet population, contradicting a hypothesis that regeneration relies on stem cells

The state's Supreme Court rules agency can start distributing grants to scientists

Dietary supplement claims to boost circulating stem cells, but is it safe?

Last week the Journal of Neuroscience published linkurl:findings;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17475797&query_hl=9&itool=pubmed_docsum suggesting antidepressant treatment stimulates neurogenesis in primates, something researchers had spotted in rodents and tree shrews previously. These results, which report neurogenesis in monkeys undergoing electroconvulsive shock (ECS), come close to confirming a hunch by linkurl:Brain Cells In

Naltrexone Molecule How pharmacogenomics might help addiction treatment 20 years ago, scientists got hooked on a single transcription factor that responds to a number of drugs of abuse. Will their work lead to treatments? By Kerry Grens ARTICLE EXTRAS 1 In 2003 David Oslin and Charles O'Brien at the University of Pennsylvania's Center for Addiction Treatment and their colleagues reported an association between this SNP and how well

Credit: Reprinted by permission of Macmillian Publishers, LTD." /> Credit: Reprinted by permission of Macmillian Publishers, LTD. The paper: T. Hessa et al., ?Recognition of transmembrane helices by the endoplasmic reticulum translocon,? Nature, 433:377?81, 2005. (Cited in 88 papers) The finding: Gunnar von Heijn

Credit: © Frank Rogozienski Photography" /> Credit: © Frank Rogozienski Photography Amy Kiger admits to a healthy dose of yeast envy from time to time. In her tidy, two-year-old lab at the University of California, San Diego, she picks up a thin tube of Drosophila to explain how she?s using the flies to investigate membrane-mediated events that guide cell shape. Yeast genetics may be faster, easier, and better worked out, but for Kiger one of the most exci

3-D Neurogenesis: Catch a 3-D glimpse of new neurons in the brain This spinning 40-micron section of rat hippocampus shows new neurons in the granule cell layer of the dentate gyrus. Mature neurons are labeled in green with NeuN and proliferating cells are labeled in red with BrDU. The video was generated by BrainCells Inc, a La Jolla, Calif. company searching for new antidepressant drugs based on their ability to stimulate neurogenesis in the hippocampus. All antidepressants on the mark

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