Richard P. Grant
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Articles by Richard P. Grant
Fountain of Youth?
Richard P. Grant | | 3 min read
Preston Estep discusses the role that telomeres play in the aging process.
Taking Shape
Richard P. Grant | | 4 min read
Floral bouquets are the most ephemeral of presents. The puzzle of how flowers get their shape, however, is more enduring.
Suffrage, art and science
Richard P. Grant | | 3 min read
An artful event hosted by the UK's Medical Research Council celebrates the role of women in research
Mitotic Hijacker
Richard P. Grant | | 3 min read
By Richard P. Grant Mitotic Hijacker HIDDEN JEWEL When a cell divides, its duplicated chromosomes have to be shared equally between the two daughter cells. Cells manage this feat by lining up replicated chromosomes along their equators during mitosis, and then pulling sister chromatids apart to the right destinations. But Theileria, an intracellular parasitic protozoan, also needs to divide when its host cell undergoes mitosis. Dirk Dobbelaere and colleagu
Come Inside
Richard P. Grant | | 2 min read
By Richard P. Grant Come Inside Lesley McKeane, MRC Visual Aids (virus) The paperD.L. Mallery et al., “Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21),” PNAS, 107:19985-90, 2010. Free F1000 Evaluation The findingAntibodies work by activating the complement cascade, preventing invading microorganisms from entering cells, or binding to a pathogen and marking it for destruction by immune cells. Now,
Bitter Pill
Richard P. Grant | | 1 min read
By Richard P. Grant Bitter Pill 3d4medical / photo researchers inc. The paperD.A. Deshpande et al., “Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction,” Nat Med, 16:1299-304, 2010. Free F1000 Evaluation The findingStephen Liggett and colleagues at the University of Maryland School of Medicine set out to identify the G-protein coupled receptors (GPCRs) involved in the cont
Calcium Kicks
Richard P. Grant | | 1 min read
By Richard P. Grant Calcium Kicks Medi-Mation ltd / Photo researchers inc. The paperM.D. Fuller et al., “Molecular mechanism of calcium channel regulation in the fight-or-flight response,” Sci Signal, 3:ra70, 2010. Free F1000 Evaluation The findingPounding heart, tight muscles, and rapid breathing are all familiar effects of the “fight or flight” response. Adrenaline receptors turn on protein kinase A (PKA), which opens ca
