Comparison of primary DNA sequences between closely related organisms is a powerful tool for identifying important, conserved genetic sequences, and the function of unknown sequences may be inferred from protein motifs and degrees of relatedness to other members of the same family. Another approach to the functional dissection of a genome is to induce mutations in genes and observe their effects on development and fertility. In the September 4
Kile et al. performed a series of three-generation breeding schemes to assess the effects of mutating genes on mouse chromosome 11, which has conserved linkage to a gene-rich...