Book excerpt from Everyday Practice of Science

In Chapter 3, “Credibility: Validating Discovery Claims,” author Frederick Grinnell details the difficulty in making discoveries that buck current scientific paradigms.

Written byFrederick Grinnell
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

OXFORD UNIVERSITY PRESS, 2011“Challenging the prevailing thought style”

Nobel Laureate Albert Szent-Györgyi’s prescription for discovery was seeing what everybody else has seen and thinking what nobody else has thought. René Magritte’s 1936 oil painting Perspicacity shows a seated artist staring at a solitary egg on a draped table. On his canvas, he paints a bird in full flight. As expressed in Szent-Györgyi’s prescription and Magritte’s painting, discovery frequently requires unconventional thinking. The more novel a discovery claim, the greater its potential to refashion the thought style and affect subsequent research in the field. At the same time, novelty also challenges intersubjectivity and can come into conflict with the prevailing thought style. As a result, highly novel discovery claims sometimes are received with considerable skepticism by the research community.

I learned firsthand the difficulty ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research