Skip to main content

Can Epigenetics Explain Homosexuality?

Scientists propose a new model for how homosexuality develops, but observers say it will be difficult to test.

Written bySabrina Richards
| 4 min read

Register for free to listen to this article
Listen with Speechify
0:00
4:00

WIKIMEDIA, theodoranian.Researchers looking for a genetic signature of homosexuality have been barking up the wrong tree, according to a trio of researchers in the United States and Sweden. Instead, the scientists posit, epigenetic influences acting on androgen signaling in the brain may underlie sexual orientation. In a paper published last week (December 11) in The Quarterly Review of Biology, they propose a model describing how epigenetic markers that steer sexual development in males could promote homosexual orientation in females, and vice versa. The scientists offer their model to explain both the tendency of homosexuality to run in families, and the fact that so far no “homosexual gene” has been identified.

“It’s a very provocative, very interesting new twist that is plausible,” said Margaret McCarthy, a neuroscientist at the University of Maryland who studies how hormones influence brain development and was not involved in producing the model. But, she cautioned, so far the theory “is not supported by any data.”

Indeed, Andrea Ciani, an evolutionary psychologist at the University of Padova, thinks that a variety of factors, including genes and epigenetics, influence sexual orientation. “It’s a little bit vain to think we’ll find the answer to homosexuality as a whole.”

The model was developed by William Rice, an evolutionary geneticist at the University of California, Santa Barbara; Sergey Gavrilets, a mathematician at the University of Tennessee; and Urban Friberg, an evolutionary biologist at the University of ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related Topics

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Miltenyi
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi

Products

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo
Conceptual image of ice and frost.

The VAULT100 PRO: Inside the most advanced Stirling Ultracold ULT freezer ever built.

Stirling Ultracold logo