Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
ABOVE: © iStock.com, Semen Salivanchuk
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

ABOVE: © iStock.com, Semen Salivanchuk

epigenetics

Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
An illustration showing a scale weighing two double-stranded pieces of DNA that has a big question mark in the center.
Mouse Foraging Behavior Shaped by Opposite-Sex Parent’s Genes
Dan Robitzski | Apr 12, 2022
A study in mice finds that for certain genes, one parent’s allele can dominate expression and shape behavior—and which parent’s allele does so varies throughout the body.
baby
Maternal smoking during pregnancy alters placental function and fetal growth
Roni Dengler, PhD | Feb 3, 2022
Smoking during pregnancy changes marks on placental DNA, altering its responses to environmental stressors.
Illustration showing epigenetic changes
Infographic: Questions Linger About Epigenetic Inheritance
Catherine Offord | Apr 4, 2022
Some studies suggest that associations between the health of children and the experiences of their parents or grandparents may be due to epigenetic mechanisms, but confounding factors challenge this interpretation.
Illustration showing two hands join, father or mother with child
Does Human Epigenetic Inheritance Deserve a Closer Look?
Catherine Offord | Apr 4, 2022
The concept of epigenetic inheritance has long been controversial. Some researchers hope that new data on cross-generational effects of environmental exposures will help settle the debate.
The Inside Scoop on Successful ATAC-seq Experiments
Technique Talk: The Inside Scoop on Successful ATAC-seq Experiments
The Scientist Creative Services Team | Jan 17, 2022
Discover how to best map a cell’s epigenetic landscape
A bright, illuminated, yellow cluster of spheres, representing a mutated base pair, stands out from a double helix of deep red base pairs joined by blue hydrogen bonds
Study: Sickle Cell Mutation Driven by Pressure, Not Random Chance
Dan Robitzski | Mar 17, 2022
New research finds that the appearance of the HbS mutation, which protects against malaria but leads to sickle cell disease when present in two copies, was more common in sperm samples from men in Ghana, where malaria risk is high, than Europeans.
health care provider standing in front of gynecology stirrups holding swabs for Pap smear
DNA Methylation Could Predict Ovarian, Breast Cancers
Anna Napolitano | Feb 11, 2022
A pair of new studies finds that analyzing material from a Pap smear can reveal tumor risk in distant parts of the body, potentially allowing early interventions.
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Capturing Heterogeneity: How Single Cell Analysis Reshapes Health and Disease Research
The Scientist Creative Services Team | Sep 30, 2021
Timothy O’Sullivan and Jacob Blum will discuss how they use single cell data to understand complex biological systems.
white mouse with pups
Doubts Raised Over Whether Mice Can Truly Inherit Immunity
David Adam | Jan 26, 2022
An independent lab fails to replicate results suggesting mammals exposed to pathogens could pass on immunological protections through epigenetic mechanisms.
A close-up image of pale green seeds inside of a green capsule taken by a scanning electron microscope
Essential Genes Protected from Mutations
Dan Robitzski | Jan 25, 2022
Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.
Methylation Sequencing to Identify Potential Cancer Biomarkeres
Methylation Sequencing in Cancer Detection
The Scientist Creative Services Team, Twist Bioscience | Aug 18, 2021
Discover how efforts to uncover the genome's methylation patterns advance cancer detection
5 images related to stories highlighted in the article, including DNA strand, insect, and dog
Our Favorite Genetics Stories of 2021
Christie Wilcox | Dec 23, 2021
Studies The Scientist covered this year illustrate the expanding importance of genetic and genomic research in all aspects of life science, from ecology to medicine.
A semi-translucent hydra, complete with a body column, head, and multiple tentacles, is pictured in front of a gray background.
How Hydras Regenerate Decapitated Heads
Dan Robitzski | Dec 14, 2021
Hydra vulgaris constantly replenish the cells in their heads and grow new ones to reproduce asexually. But gene expression analyses reveal that regenerating a head after an injury is a very different process.
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Investigating Genetic and Epigenetic Landscapes with Long-Read Sequencing
The Scientist Creative Services Team in collaboration with Oxford Nanopore | Aug 13, 2021
Matthew Naish will discuss what he learned about Arabidopsis thaliana centromeres from long-read sequencing experiments.
Image of the tissue surrounding a pancreatic tumor thickening and scarring.
How Pancreas Injuries Can Cause Cancer in Mice
Dan Robitzski | Nov 9, 2021
A key mutation turns healing cells into cancer promoters.
white adult mouse with 4 pups on white background
Mice that Survive Infection Pass on Stronger Immunity
David Adam | Oct 18, 2021
Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.
Technique Talk: Single Cell Sequencing Sample Preparation for Oncology Research
The Scientist Creative Services Team in collaboration with 10x Genomics | Apr 29, 2021
In this workshop, learn tips and tricks for preparing cancer tissue samples for a variety of single cell applications.
A Black woman stands in profile with her head turned towards the camera, smiling
Bianca Jones Marlin Traces How Sensory Inputs Shape the Brain
Annie Melchor | Oct 1, 2021
The Columbia University neuroscientist researches the biology behind some of our most human experiences, including building family relationships.