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A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

epigenetics
composite of images from favorite posts
Our Favorite Genetics Stories of 2022
Christie Wilcox, PhD | Dec 22, 2022 | 4 min read
This year’s stories highlight the expanding versatility of genetic techniques and the increasing utility of such research in all life science fields.
zebrafish in an aquarium
Epigenetics May Remember Ancestors’ Mutations
Holly Barker | Dec 1, 2022 | 4 min read
Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.
Methylation Sequencing to Identify Potential Cancer Biomarkeres 
Methylation Sequencing in Cancer Detection
The Scientist’s Creative Services Team and Twist Bioscience | 1 min read
Discover how efforts to uncover the genome's methylation patterns advance cancer detection.
Blue 3D illustration of X-shaped chromosomes
X Chromosome Silenced in Some Cancers in Males
Natalia Mesa, PhD | Nov 11, 2022 | 3 min read
A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 
Illustration from the epigenetics and the genome infographic
Infographic: How Epigenetic Marks Can Change the Genome
Katarina Zimmer | Nov 1, 2022 | 2 min read
Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.
VAI
One Sequence, Many Variations
Van Andel Institute | 5 min read
Andrew Pospisilik explores the epigenetic changes that give organisms the plasticity to change in response to their environments.
Cellular DNA and epigenetics
Do Epigenetic Changes Influence Evolution?
Katarina Zimmer | Nov 1, 2022 | 10+ min read
Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.
A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Alejandra Manjarrez, PhD | Oct 19, 2022 | 4 min read
Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.
VAI
Exposed: Environmental Echoes in Health - A Special Podcast Series
The Scientist’s Creative Services Team and Van Andel Institute | 2 min read
Epigenetic experts discuss how environment and diet leave lasting impressions on the human genome.
white mouse sitting down
Drug Spurs Neuron Growth in Mice with Chronic Spinal Cord Injury
Natalia Mesa, PhD | Sep 27, 2022 | 4 min read
A protein duo increases transcription of growth-related genes to enhance axon regeneration and boost plasticity, a study finds—but fails to improve mobility.
Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa, PhD | May 20, 2022 | 4 min read
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
The Epigenetic Landscape During T Cell Exhaustion
The Epigenetic Landscape During T Cell Exhaustion
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
In this webinar, E. John Wherry and Debattama Sen will discuss how epigenetic scarring of exhausted T cells influences chronic infections.
Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022 | 4 min read
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
An illustration showing a scale weighing two double-stranded pieces of DNA that has a big question mark in the center.
Mouse Foraging Behavior Shaped by Opposite-Sex Parent’s Genes
Dan Robitzski | Apr 12, 2022 | 7 min read
A study in mice finds that for certain genes, one parent’s allele can dominate expression and shape behavior—and which parent’s allele does so varies throughout the body.
Setting High Standards for Antibody Production Using Nucleosomes
Setting High Standards for Antibody Production Using Nucleosomes
Fortis Life Sciences | 3 min read
A unique approach to antibody production that exposes antibody candidates to nucleosomes is revolutionizing best practices.
Illustration showing epigenetic changes
Infographic: Questions Linger About Epigenetic Inheritance
Catherine Offord | Apr 4, 2022 | 3 min read
Some studies suggest that associations between the health of children and the experiences of their parents or grandparents may be due to epigenetic mechanisms, but confounding factors challenge this interpretation.
Illustration showing two hands join, father or mother with child
Does Human Epigenetic Inheritance Deserve a Closer Look?
Catherine Offord | Apr 4, 2022 | 10+ min read
The concept of epigenetic inheritance has long been controversial. Some researchers hope that new data on cross-generational effects of environmental exposures will help settle the debate.
baby
Maternal smoking during pregnancy alters placental function and fetal growth
Roni Dengler, PhD | 2 min read
Smoking during pregnancy changes marks on placental DNA, altering its responses to environmental stressors.
A bright, illuminated, yellow cluster of spheres, representing a mutated base pair, stands out from a double helix of deep red base pairs joined by blue hydrogen bonds
Study: Sickle Cell Mutation Driven by Pressure, Not Random Chance
Dan Robitzski | Mar 17, 2022 | 6 min read
New research finds that the appearance of the HbS mutation, which protects against malaria but leads to sickle cell disease when present in two copies, was more common in sperm samples from men in Ghana, where malaria risk is high, than Europeans.
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