Can Preventing Seizures Alter the Course of Autism?

Experimental surgeries to prevent seizures may help scientists understand the link between autism and epilepsy.

| 11 min read
autism epilepsy seizures deep brain stimulation

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ABOVE: WILLIAM MEBANE FOR SPECTRUM

Delicate lines dance across a screen mounted on the wall of the operating room. Their peaks and valleys become pronounced, suddenly flatten into a straight line—and then return, stronger than before.

These digital traces represent the buzz of neurons in 12-year-old Kevin Lightner, read by two thin electrodes that surgeons have inserted deep into his brain. Kevin, who has autism and has had seizures since he was 8 years old, lies uncharacteristically still in the center of the room, draped under a blue sheet, his tiger-print pajamas neatly folded on a nearby shelf.

What’s happening in this room may be the last chance to bring Kevin’s seizures under control.

An hour and a half ago, neurosurgeon Saadi Ghatan removed a roughly 2-inch by 1-inch piece of the top of Kevin’s skull. He replaced it with a rectangular metal device, carefully screwed into the newly exposed ...

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