Mario Capecchi of the University of Utah, Sir Martin Evans of Cardiff University in the UK and Oliver Smithies of University of North Carolina, Chapel Hill, will share this year's Nobel Prize in Physiology or Medicine for their work in gene manipulation that let to the development of knockout mice. Learning this morning that he had received the award filled him with a "sense of peace," Smithies told The Scientist. "It was a nice finale to a life's work."Since the first knockout mouse publications in 1989, the technique has become ubiquitous in mammalian biology, allowing researchers to investigate gene function and to create animal models for diseases."People have been expecting this since the 1990s," said Jeremy M. Berg, director of The National Institute of General Medical Sciences. "The surprise is that they hadn't won it before."The trio started from different lines of research, but in the 1980s, their work...

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