Chromatrap announces that its popular Native ChIP kit is now fully compatible for mass spectrometry (MS) as a downstream process. Combining Chromatrap®’s unique solid-state ChIP technology with MS enables researchers to obtain high quality data sets for chromatin proteomic profiling and mapping of histone modification patterns.

The Chromatrap® Native ChIP (N-ChIP) kit is widely proven to ensure a high yield of DNA so that samples can be analysed by multiple downstream processes. Leveraging Chromatrap®’s unique solid-state technology, the N-ChIP kit eliminates the use of magnetic or agarose beads allowing users to quickly and easily recover ready-to-use, purified chromatin for downstream applications, including mass spectroscopy. Coupling MS to ChIP will allow researchers to shed light on the proteomic landscape of the extracted chromatin enabling them to begin to understand how proteins interact with repressed and active regions of the genome and their role in global gene regulation. 

Chromatin immunoprecipitation (ChIP) is...

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