As the age of the general population increases, so does the need for precision treatments for age-related cardiac health decline. Heart failure is a rising global cardiovascular epidemic driven by aging and chronic inflammation. However, despite research efforts to establish heart failure drivers and understand the pathophysiology of age-related heart failure, strategies for prevention or treating the root cause remain elusive.1
Cells become senescent when they reach a certain age that signals them to stop growing and dividing. Senescent cells secrete various proteins involved in cellular aging and pathological processes, including the metabolic protein insulin-like growth factor-binding protein-7 (IGFBP7). Using proteomics, researchers identified IGFBP7 as a potential biomarker for heart failure, and in 2017, the American Heart Association recognized this protein as an important biomarker for heart failure prognosis and diagnosis based on clinical data. Its involvement in the underlying pathology of heart failure is of interest to scientists and ...
