Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.

Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.

As male Drosophila grow old, selfish genetic elements that are abundant on the Y chromosome become more active, which appears to reduce longevity.

The researchers behind the results propose that an exercise-induced protein in circulation is responsible for the benefits.

Experts will explore how RNAi mechanisms can modulate gene expression for the treatment of neurodegenerative diseases and how new methods for their use are being developed. 

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.

Oxidative stress associated with aging damages ovarian cells in both humans and nonhuman primates.

While the findings contradict previous studies that have linked human herpesvirus 6 to the neurodegenerative disease, they do not eliminate the possibility of a relationship.

Genes related to the immune system stay active throughout the tree’s life.

Suppressing the natural age-related increase in neuronal excitation lengthens the lives of worms, and there are indications that the same may be true for mice and humans.

The researchers intend for the tool to eventually help doctors make treatment decisions.

Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.

Lucie Low, a project leader for Tissue Chips in Space, describes the experiments that are slated to blast off later this week.