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Illustration of a web of dark blue neurons with a purple glow at the center of each neuron.
How the Brain Hits the Brakes on Aging 
Neurons linked to metabolic processes slow aging in mice.
How the Brain Hits the Brakes on Aging 
How the Brain Hits the Brakes on Aging 

Neurons linked to metabolic processes slow aging in mice.

Neurons linked to metabolic processes slow aging in mice.

aging

Back Pain Explained
Rachael Moeller Gorman | Feb 5, 2024 | 4 min read
Not all degenerated intervertebral discs are painful; a new study identified a subset of disc cells that triggers a pathway to pain.
A Molecular Switch for Bone Loss
Mariella Bodemeier Loayza Careaga, PhD | Jan 23, 2024 | 4 min read
Blocking an abnormally active signaling pathway in skeletal stem and progenitor cells alleviates bone mass decline in middle-aged mice. 
Aging and Cancer
Aging and Cancer
Rebecca Roberts, PhD | 6 min read
The relationship between aging and cancer is complex, with several shared underlying mechanisms. 
Cropped view of senior man playing with puzzles
A Rare Genetic Mutation Protects Against Alzheimer's Disease
Hannah Thomasy, PhD, Drug Discovery News | Sep 17, 2023 | 4 min read
Data from a highly resilient individual guided researchers to new potential therapeutic targets.
Close up on eyes of mother and daughter faces next to one another
A Long and Unhealthy Life?
Aparna Nathan, PhD | Sep 13, 2023 | 3 min read
A new mouse model shows that the Myc protein has complex effects on aging and cancer.
Cellular Senescence: Why Do Cells Stop Dividing?
Cellular Senescence: Why Do Cells Stop Dividing?
Elina Kadriu | 4 min read
Senescent cells undergo major morphological and metabolic changes when at the end of their lifespan. 
Melanocyte stem cells are shown in red and other cell nuclei are shown in blue.
Hair Turns Gray Due to Stuck Stem Cells
Mariella Bodemeier Loayza Careaga, PhD | Sep 8, 2023 | 3 min read
Hair-coloring stem cells must swing back and forth between their maturity states to give hair its color.
An elderly person in beige shirt and a knitted, cream-colored vest holds a wooden walking stick.
New Epigenetic Clocks May Confirm Extreme Age
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
How will a new version of epigenetic clocks aimed at validating the age of people older than 100 years of age balance accuracy and anonymity?
The fight against time
The Scientist Speaks - The Fight Against Time: Stem Cells and Healthy Aging 
The Scientist | 2 min read
Tricking the body into mimicking a fasting state may hold the key to fighting age-related cognitive decline. 
Woman smiling at the camera working out on a blue yoga mat.
Keeping Older Muscles Strong
Hannah Thomasy, PhD, Drug Discovery News | Sep 5, 2023 | 5 min read
From stem cell-recruiting gels to hormone cycle restoration, Tracy Criswell has big ideas about how to combat age-related decline in muscle regeneration.
Old brown dog with gray on its face and neck
Aging Dogs Provide Insights for Human Longevity
Hannah Thomasy, PhD, Drug Discovery News | Jul 19, 2023 | 6 min read
Biogerontologist Matt Kaeberlein studies aging pets to determine how to improve healthspan in dogs and their humans.
A mole-rat poses in the grass 
The Scientist Speaks - Exploring the Secrets to Longevity and Cancer Resistance in Mole-Rats
The Scientist | 1 min read
Vera Gorbunova discusses what naked and blind mole-rat cells reveal about aging and cancer resistance mechanisms. 
Image of yeast cells
Yeast Cells Reconfigure Their Metabolomes to Live Longer
Danielle Gerhard, PhD | Jul 5, 2023 | 2 min read
Yeast cells share metabolites through extracellular space to extend the lifespan of the entire community.
TKTK
Time Traveling Mini-Brains on a Mission to Conquer Space
Iris Kulbatski, PhD | Jun 1, 2023 | 5 min read
Alysson Muotri launched brain organoids into outer space and found that microgravity enriches our understanding of brain development and disease.
A person holding a section of his face and looking in to his brain through a magnifying glass stock illustration
Science Philosophy in a Flash - A Look at Aging Through Young Eyes 
Iris Kulbatski, PhD | 1 min read
Aimée Parker shares how her childlike curiosity and collaborative spirit motivate her scientific pursuits.
Elderly woman holding cell phone
A New Smartphone Application Improves Memory Recall in Older Adults
Mariella Bodemeier Loayza Careaga, PhD | May 8, 2023 | 3 min read
Neuroscientists developed and tested a promising mobile app that mitigates age-related memory decline.
Artist’s rendition of orange DNA coiled around a blue histone protein.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
Kamal Nahas, PhD | Apr 6, 2023 | 4 min read
Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.
A Rising Star Launches Brain Power into Outer Space
Science Philosophy in a Flash - A Rising Star Launches Brain Power into Outer Space
Iris Kulbatski, PhD | 1 min read
Alysson Muotri shares how tapping into his inner creative spark fuels his pursuit of science.
mouse
hCINAP Protein Key to Cellular Senescence: Study
Patience Asanga | Mar 23, 2023 | 3 min read
The authors claim that by preventing the formation of senescent cells, the protein could delay aging, but experts are skeptical.
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